Evidence map›Paper›PMID 40025185›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2025

Serum 25-hydroxyvitamin D levels and peripheral blood eosinophil percentages as predictive indicators for eosinophilic chronic sinusitis with nasal polyps.

Jianqi Wang, Yuwei Jiang, Xiaohong Chen, Junming Ma, Yue Li, Weiqiang Huang, Yanjie Jiang, Haotian Wu, Xia Li, Xifu Wu and 4 more

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Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Jianqi Wang *Department of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tianhe Road, Guangzhou, 510630, China.
Yuwei Jiang *Medical Examination Center, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Xiaohong Chen *Department of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tianhe Road, Guangzhou, 510630, China.
Junming MaDepartment of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tianhe Road, Guangzhou, 510630, China.
Yue LiDepartment of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tianhe Road, Guangzhou, 510630, China.
Weiqiang HuangDepartment of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tianhe Road, Guangzhou, 510630, China.
Yanjie JiangDepartment of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tianhe Road, Guangzhou, 510630, China.
Haotian WuDepartment of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tianhe Road, Guangzhou, 510630, China.
Xia LiDepartment of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tianhe Road, Guangzhou, 510630, China.
Xifu WuDepartment of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tianhe Road, Guangzhou, 510630, China.
Zizhen HuangDepartment of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tianhe Road, Guangzhou, 510630, China.
Yana ZhangDepartment of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tianhe Road, Guangzhou, 510630, China.
Lihong ChangDepartment of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tianhe Road, Guangzhou, 510630, China. changlh3@mail.sysu.edu.cn.
Gehua ZhangDepartment of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tianhe Road, Guangzhou, 510630, China. zhanggeh@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0002-1917-0283

Funding

National Natural Science Foundation of China 82271145
6 · The paper itself

Abstract

purposeChronic rhinosinusitis (CRS) has a high incidence rate and different endotypes. Serum 25-hydroxyvitamin D (25(OH)D) deficiency is common in patients with eosinophilic and non-eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP and nECRSwNP, respectively). This study explored the relationship between serum 25(OH)D levels and CRS risk and determined the value of combining serum 25(OH)D with peripheral blood markers in distinguishing between ECRSwNP and nECRSwNP.

methodsThis study enrolled 275 CRS patients and 298 healthy controls. The relationship between serum 25(OH)D levels and CRS risk was determined using logistic regression after propensity score matching (PSM). The efficiency of various peripheral blood markers in distinguishing between ECRSwNP and nECRSwNP was assessed using a decision-tree model.

resultsThe final analysis included 189 CRS patients and 189 controls after 1:1 PSM. Serum 25(OH)D levels were significantly lower in CRS patients than in controls. Patients with mild CRS showed higher serum 25(OH)D levels than those with moderate or severe CRS, and ECRSwNP patients had lower serum 25(OH)D levels than nECRSwNP patients (all Ps < 0.05). Eosinophil percentages and IgE levels were independent risk factors for ECRSwNP, whereas serum 25(OH)D was an independent protective factor. 25(OH)D deficiency increased the ECRSwNP risk (OR = 3.074, P = 0.04). An eosinophil percentage ≥ 5% and a 25(OH)D level < 61.8 nmol/L could be used to predict ECRSwNP, with training and test set accuracies of 89.7% and 85.7%, respectively.

conclusionOur findings suggest that serum 25(OH)D deficiency is an independent risk factor for CRS, especially ECRSwNP. Combining serum 25(OH)D levels with peripheral eosinophil percentages could be a promising biomarker for ECRSwNP.

Indexed as

EosinophiliaEosinophilsNasal PolypsRhinitisSinusitisVitamin DAdultBiomarkersCase-Control StudiesChronic DiseaseFemaleHumansMaleMiddle AgedPredictive Value of TestsVitamin D Deficiency25-hydroxyvitamin DBiomarkersVitamin DChronic rhinosinusitisEosinophilsPropensity score matchingVitamin D

Identifiers

PMID40025185

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.