Evidence map›Paper›PMID 40025167›Full record

ArticleExperimental & molecular medicine2025

sLZIP functions as a key modulator of bone remodeling by regulating the crosstalk between osteoblasts and osteoclasts.

Sungyeon Park, Jeonghan Kim, Jesang Ko

Abstract read
In one paragraph

Article in Experimental & molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sungyeon ParkDivision of Life Sciences, Korea University, Seoul, South Korea.
Jeonghan KimDepartment of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul, South Korea.ORCID http://orcid.org/0000-0003-1695-9630
Jesang KoDivision of Life Sciences, Korea University, Seoul, South Korea. jesangko@korea.ac.kr.ORCID http://orcid.org/0000-0002-7609-9719

Funding

Korea University (KU) Korea University GrantNational Research Foundation of Korea (NRF) RS-2023-00210934National Research Foundation of Korea (NRF) RS-2023-00220840
6 · The paper itself

Abstract

Human small leucine zipper protein (sLZIP) regulates the differentiation of both osteoblasts (OBs) and osteoclasts (OCs). However, the regulatory role of sLZIP in bone remodeling and its involvement in bone disorders remain unclear. Here we investigated the role of sLZIP in bone remodeling and its importance in the development of cell therapies for bone diseases. sLZIP increased bone mass in an osteoporosis mouse model. Moreover, bone mass was lower in mesenchymal stem cell-specific murine LZIP-1/2 knockout (Osx-LZIP-1/2

Indexed as

Bone RemodelingCell CommunicationOsteoblastsOsteoclastsAnimalsCell DifferentiationDisease Models, AnimalHumansMesenchymal Stem CellsMiceMice, KnockoutOsteogenesisOsteoporosis

Identifiers

PMID40025167
PMCPMC11958637

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.