Evidence map›Paper›PMID 40025163›Full record

ArticleScientific reports2025

Mutations in the voltage-gated sodium channel associated with permethrin resistance in Rhipicephalus linnaei populations in Thailand.

Ratree Takhampunya, Wasinee Ngonsawan, Asma Longkunan, Siriporn Phasomkusolsil, Sommai Promsathaporn, Bousaraporn Tippayachai, Jira Sakolvaree, Alyssa N Mann, Erica J Lindroth

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Ratree TakhampunyaDepartment of Entomology, Walter Reed Army Institute of Research-Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
Wasinee NgonsawanDepartment of Entomology, Walter Reed Army Institute of Research-Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
Asma LongkunanDepartment of Entomology, Walter Reed Army Institute of Research-Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
Siriporn PhasomkusolsilDepartment of Entomology, Walter Reed Army Institute of Research-Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
Sommai PromsathapornDepartment of Entomology, Walter Reed Army Institute of Research-Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
Bousaraporn TippayachaiDepartment of Entomology, Walter Reed Army Institute of Research-Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
Jira SakolvareeDepartment of Entomology, Walter Reed Army Institute of Research-Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
Alyssa N MannDepartment of Entomology, Walter Reed Army Institute of Research-Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
Erica J LindrothDepartment of Entomology, Walter Reed Army Institute of Research-Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand. Erica.Lindroth.mil@afrims.org.

Funding

Armed Forces Health Surveillance Branch, Global Emerging Infections Surveillance and Response System (AFHSB-GEIS), Silver Spring, Maryland, USA P0035_24_AF
6 · The paper itself

Abstract

Insecticide resistance is a serious threat to vector control programs worldwide. Therefore, it is crucial to monitor the development of resistance in vector populations. Rhipicephalus linnaei (Audouin, 1826) is a cosmopolitan tick and a vector of medically important pathogens. We conducted a comprehensive investigation of permethrin resistance in larvae of Rh. linnaei populations across Thailand by comparing phenotypic resistance with tick genotypes, focusing on mutations in Domain II and III of the voltage-gated sodium channel gene. Results showed that larvae obtained from engorged female tick populations in Thailand have developed resistance to permethrin, with levels varying by location. Resistance ratios ranged from 1 to 56 when compared to the least susceptible local population. Genotyping identified mutations at positions 190 (c.190C > A and c.190C > G) and 2134 (c.2134T > C) in Domain II and Domain III, respectively, which are correlated with phenotypic resistance. We identified new alleles c.190CG and c.190AG in highly resistant populations from Phasichareon, Bangkok, and Chonburi provinces. This study provides the first evidence, to our knowledge, of permethrin resistance in Rh. linnaei ticks in Thailand. Elevated levels of permethrin resistance in Rh. linnaei populations across Thailand indicate that veterinarians and farmers should consider tick control products with alternative modes of action.

Indexed as

Insecticide ResistanceMutationPermethrinRhipicephalusVoltage-Gated Sodium ChannelsAnimalsFemaleGenotypeLarvaThailandPermethrinVoltage-Gated Sodium ChannelsHaplotype analysisLarval packet testPermethrin resistanceRhipicephalus linnaeiVoltage-gated sodium channel

Identifiers

PMID40025163
PMCPMC11873048

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