Evidence map›Paper›PMID 40025148›Full record

ArticleScientific reports2025

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Isabel Day, Mikayla Tamboline, Lindsay Lueptow, Irina Zhuravka, Taryn Diep, Ilona Tkachyova, Shili Xu, Andreas Schulze, Gerald S Lipshutz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Isabel Day *Department of Surgery, David Geffen School of Medicine at UCLA, 757 Westwood Plaza, Room 8501G, Los Angeles, CA, 90095-7054, USA.
Mikayla Tamboline *Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Lindsay LueptowDepartment of Psychology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Irina ZhuravkaDepartment of Psychology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Taryn DiepDepartment of Surgery, David Geffen School of Medicine at UCLA, 757 Westwood Plaza, Room 8501G, Los Angeles, CA, 90095-7054, USA.
Ilona TkachyovaResearch Institute, The Hospital for Sick Children, University of Toronto, Toronto, ON, M5G 1X8, Canada.
Shili XuDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Andreas SchulzeResearch Institute, The Hospital for Sick Children, University of Toronto, Toronto, ON, M5G 1X8, Canada.
Gerald S LipshutzDepartment of Surgery, David Geffen School of Medicine at UCLA, 757 Westwood Plaza, Room 8501G, Los Angeles, CA, 90095-7054, USA. glipshutz@mednet.ucla.edu.

Funding

California Institute for Regenerative Medicine DISC2-14090
6 · The paper itself

Abstract

Pathogenic variants in the creatine transporter gene SLC6A8, reported to represent 2% of all intellectual disabilities in males, result in a spectrum of behavioral abnormalities including developmental delay, intellectual disability, and deficit in speech. While at present there are no effective treatments available, preclinical development and testing of gene therapy and other approaches to increase brain creatine are being actively pursued. In studying a mouse model of the disorder, [

Indexed as

BrainFluorodeoxyglucose F18Loss of Function MutationPlasma Membrane Neurotransmitter Transport ProteinsPositron-Emission TomographyAnimalsBiomarkersCreatineDisease Models, AnimalGlucoseMaleMembrane Transport ProteinsMicePositron Emission Tomography Computed TomographyX-Linked Intellectual DisabilityBiomarkersCreatinecreatine transporterFluorodeoxyglucose F18GlucoseMembrane Transport ProteinsPlasma Membrane Neurotransmitter Transport Proteins[18F]fluorodeoxyglucose[18F]MPPFCreatineCRT-1 transporter deficiencyGlucosePET-CTSerotoninSLC6A8 mutations

Identifiers

PMID40025148
PMCPMC11873236

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.