Evidence map›Paper›PMID 40025135›Full record

ArticleArchives of toxicology2025

Imbalance of human CD4

Mahdieh Naghavi Alhosseini, Ambra Maddalon, Luigi Cari, Simona Ronchetti, Graziella Migliorati, Emanuela Corsini, Giuseppe Nocentini

Abstract read
In one paragraph

Article in Archives of toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mahdieh Naghavi AlhosseiniDepartment of Medicine and Surgery, Section of Pharmacology, Università degli Studi di Perugia, Building D, Severi Square 1, 06129, Perugia, Italy.
Ambra MaddalonLaboratory of Toxicology, Department of Pharmacological and Biomolecular Sciences, "Rodolfo Paoletti", Università degli Studi di Milano, Via Balzaretti 9, 20133, Milan, Italy.
Luigi CariDepartment of Medicine and Surgery, Section of Pharmacology, Università degli Studi di Perugia, Building D, Severi Square 1, 06129, Perugia, Italy. luigi.cari@unipg.it.ORCID 0000-0003-0698-3872
Simona RonchettiDepartment of Medicine and Surgery, Section of Pharmacology, Università degli Studi di Perugia, Building D, Severi Square 1, 06129, Perugia, Italy.
Graziella MiglioratiDepartment of Medicine and Surgery, Section of Pharmacology, Università degli Studi di Perugia, Building D, Severi Square 1, 06129, Perugia, Italy.
Emanuela CorsiniLaboratory of Toxicology, Department of Pharmacological and Biomolecular Sciences, "Rodolfo Paoletti", Università degli Studi di Milano, Via Balzaretti 9, 20133, Milan, Italy.
Giuseppe NocentiniDepartment of Medicine and Surgery, Section of Pharmacology, Università degli Studi di Perugia, Building D, Severi Square 1, 06129, Perugia, Italy.

Funding

Ministero dell'Università e della Ricerca 2017MLC3NF
6 · The paper itself

Abstract

While being banned in the European Union, the herbicide atrazine (ATR) is still one of the most used herbicides in the world. ATR is classified as an endocrine disruptor, but the immunotoxic effects of ATR may also be due to its direct impact on immune cells. To study the effects of ATR on human T cells, we activated T cells present in PBMCs of 8 healthy donors in the presence of ATR (0.1-100 μM). After 4 days of culture, T cells were stained to evaluate cell growth and phenotype by flow cytometry. The results demonstrated that ATR treatment exerts an antiproliferative activity on CD4

Indexed as

AtrazineCD4-Positive T-LymphocytesEndocrine DisruptorsHerbicidesT-Lymphocyte SubsetsAdultCell ProliferationCells, CulturedCytokinesDose-Response Relationship, DrugFemaleHumansLymphocyte ActivationMaleTh2 CellsAtrazineCytokinesEndocrine DisruptorsHerbicidesAtrazineCytokinesEndocrine disruptorHuman studyIn vitro studyT cell differentiation

Identifiers

PMID40025135
PMCPMC11968556

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.