Evidence map›Paper›PMID 40025084›Full record

ArticleScientific reports2025

Validation of a whole blood coagulometer sensitive to the direct oral anticoagulants.

Sasha H Bakhru, Xuan Jiang, Lirong Chen, Dardan Osmani, Kelly Kronen, Daryl Mootoo, Stefan Zappe, Jack Ansell

Abstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Anticoagulation Stewardship Program in the DOAC Era.Journal of clinical medicine · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sasha H BakhruPerosphere Technologies Inc, 108 Mill Plain Rd, Danbury, CT, 06811, USA.
Xuan JiangPerosphere Technologies Inc, 108 Mill Plain Rd, Danbury, CT, 06811, USA.
Lirong ChenPerosphere Technologies Inc, 108 Mill Plain Rd, Danbury, CT, 06811, USA.
Dardan OsmaniPerosphere Technologies Inc, 108 Mill Plain Rd, Danbury, CT, 06811, USA.
Kelly KronenPerosphere Technologies Inc, 108 Mill Plain Rd, Danbury, CT, 06811, USA.
Daryl MootooPerosphere Technologies Inc, 108 Mill Plain Rd, Danbury, CT, 06811, USA.
Stefan ZappePerosphere Technologies Inc, 108 Mill Plain Rd, Danbury, CT, 06811, USA.
Jack AnsellHofstra Northwell Zucker School of Medicine, Hempstead, NY, USA. ansellje@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Readily available and rapid turn-around, bedside assays to measure the effect of the direct oral anticoagulants (DOACs) are not available. This study evaluates a point-of-care (PoC) coagulometer to assess the anticoagulant effects of the DOACs and low molecular weight heparin. Studies were done in fresh spiked blood from healthy volunteers. PoC coagulometer baseline clotting times were half that of the manual whole blood clotting time (WBCT, legacy method) and exhibited a sensitivity to DOAC anticoagulation approximately twice that of WBCT. All %CV values for both methods were < 10% with most being < 5% indicating acceptable precision of both methods. R

Indexed as

AnticoagulantsBlood CoagulationAdministration, OralBlood Coagulation TestsHeparin, Low-Molecular-WeightHumansPoint-of-Care SystemsPyrazolesPyridonesReproducibility of ResultsRivaroxabanWhole Blood Coagulation TimeAnticoagulantsapixabanHeparin, Low-Molecular-WeightPyrazolesPyridonesRivaroxabanAnticoagulationCoagulation assayCoagulometerDirect oral anticoagulantsPoint-of-care

Identifiers

PMID40025084
PMCPMC11873143

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.