ArticleNature communications2025
Genomically defined hypervirulent Klebsiella pneumoniae contributed to early-onset increased mortality.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association of Klebsiella pneumoniae sequence type 11 but not other virulence factors with patient mortality: a systematic review and meta-analysis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Pooled it
- Definitional ambiguity and the dual threat of Hypervirulent Klebsiella pneumoniae infections: a systematic review and meta-analysis.Infection · 2026Pooled it
- Clinical and genomic profiling ofVirulence · 2026Article
- RpoE-mediated virulence attenuation elicits protective immunity in hypervirulentEmerging microbes & infections · 2026Article
- HypervirulentOpen forum infectious diseases · 2026Article
- Article
- Tet-ON and Tet-OFF regulation in hypervirulentMicrobiology spectrum · 2026Article
- Not so innocent: Environmental Klebsiella pneumoniae disseminating resistance and virulence via conjugation.World journal of microbiology & biotechnology · 2026Article
- Molecular characteristics and analysis of drug resistance-virulence correlation of carbapenem-resistantMicrobiology spectrum · 2026Article
- Genomic and functional approaches point to potential determinants of neonatalMicrobiology spectrum · 2026Article
- Pan-genome analysis and phylogenetic characterization ofFuture microbiology · 2026Article
- Revisiting definitions of hypervirulent and classical Klebsiella pneumoniae through virulence factors and disease phenotype.Communications medicine · 2026Article
- Two case reports on the identification and management of hypervirulentASM case reports · 2026Article
- Emergence of hypervirulent Klebsiella pneumoniae ST111 with a novel virulence plasmid causing pyogenic liver abscess.BMC microbiology · 2026Article
- Carbapenem resistance and hypervirulence iniScience · 2026Review
- Epidemiology, Virulence Factors, and Antibacterial Resistance ofMedicina (Kaunas, Lithuania) · 2026Review
- Molecular detection of hypervirulent Klebsiella pneumoniae (hvKp) in Egyptian poultry.BMC veterinary research · 2026Article
- Genomic epidemiology of extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in Mwanza, Tanzania.Journal of global antimicrobial resistance · 2026Article
- Genomic epidemiology of putative hypervirulentMicrobiology spectrum · 2026Article
- Article
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Authors and funding
7 authors.
Funding
Abstract
The presence of all five of the virulence-associated genes iucA, iroB, peg-344, rmpA, and rmpA2 is presently the most accurate genomic means for predicting hypervirulent Klebsiella pneumoniae (hvKp-p). With this longitudinal cohort study, we firstly provide novel insights into the clinical and genomic characteristics of hvKp-p in high-risk regions. Through propensity score matching, we show that hvKp-p is less likely to acquire antimicrobial resistance but develops more severe disease and result in increased mortality. HvKp-p are predominantly isolated from hospital settings and caused pneumonia in majority of the cases. ST23 and KL1 are the most common types in the hvKp-p cohort. Community-acquired and healthcare-associated infections are also identified as independent risk factors for hvKp-p. This genomic definition, albeit imperfect, offers a practical and efficient alternative to murine models, allowing for early identification and timely intervention in clinical settings.
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