Evidence map›Paper›PMID 40024993›Full record

ArticleOphthalmology and therapy2025

Hydroxypropyl-Methylcellulose and GlicoPro

Edoardo Villani, Giuseppe Campagna, Valentina Gentili, Elisa Imelde Postorino, Paola Genovese, Paola Palino, Gloria Maini, Alice Carbucicchio, Eleonora Ferioli, Paolo Nucci and 2 more

2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ophthalmology and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06726525 phase4completednot on this map

Hydroxypropyl-methylcellulose and GlicoPro® Eyedrops in the Treatment of Dry Eye Disease: Clinical Study

TypeinterventionalSponsorUniversity of MilanRan2024 to 2024Enrolled44ConditionsDry EyeArmsHPMC+GlicoPro eyedrops, Hydroxypropyl-methylcellulose
NCT07185854 nacompletednot on this map

Acupuncture Combined With Artificial Tears Compared With Artificial Tears Alone in Moderate Dry Eye: A Randomized Controlled Trial

TypeinterventionalSponsorNadide KocaRan2024 to 2025Enrolled90ConditionsDry Eye, AcupunctureArmsArtificial tears, Traditional Chinese Medicine Acupuncture
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Edoardo VillaniDepartment of Clinical Science and Community Health, University of Milan, Milan, Italy. edoardo.villani@unimi.it.ORCID http://orcid.org/0000-0003-3811-5893
Giuseppe CampagnaDepartment of Medical-Surgical Sciences and Translational Medicine, University of Rome "Sapienza", Rome, Italy.
Valentina GentiliDepartment of Environmental and Prevention Sciences, University of Ferrara, Ferrara, Italy.
Elisa Imelde PostorinoDepartment of Biomedical Sciences, Ophthalmology Clinic, University of Messina, Messina, Italy.
Paola GenoveseDepartment of Biomedical Sciences, Ophthalmology Clinic, University of Messina, Messina, Italy.
Paola PalinoDepartment of Biomedical Sciences, Ophthalmology Clinic, University of Messina, Messina, Italy.
Gloria MainiDepartment of Environmental and Prevention Sciences, University of Ferrara, Ferrara, Italy.
Alice CarbucicchioEye Clinic San Giuseppe Hospital, IRCCS Multimedica, Via San Vittore 12, 20100, Milan, Italy.
Eleonora FerioliEye Clinic San Giuseppe Hospital, IRCCS Multimedica, Via San Vittore 12, 20100, Milan, Italy.
Paolo NucciDepartment of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.
Roberta Rizzo *Department of Environmental and Prevention Sciences, University of Ferrara, Ferrara, Italy.
Pasquale Aragona *Department of Biomedical Sciences, Ophthalmology Clinic, University of Messina, Messina, Italy.

Funding

FB Vision Unnumbered
6 · The paper itself

Abstract

introductionArtificial tear substitutes are key elements in the first-line treatment of dry eye disease (DED). We hypothesized that GlicoPro

methodsWe performed an in vitro experiment and a clinical study, comparing an HPMC + GlicoPro

resultsIn vitro experiment: under hyperosmotic conditions, corneal epithelial cells upregulated the expression of inflammatory cytokines IL-20, IL-1β, TNF-α, IL-6, and IL-8. Treatment with HPMC + GlicoPro CLINICAL STUDY: the HPMC + GlicoPro

conclusionsBoth in vitro and clinical data provided evidence supporting the role of GlicoPro CLINICAL

trial registrationNCT06726525.

Indexed as

Artificial tears substituteDry eye diseaseDry eye symptomsGlicoPro®Hydroxypropyl methylcelluloseInflammationLacricomplex®Tear film stability

Identifiers

PMID40024993
PMCPMC11920458

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.