Evidence map›Paper›PMID 40024992›Full record

ArticleJournal of natural medicines2025

New abietane-type diterpenoids from roots of Euonymus hamiltonianus and their cytotoxicity in human cancer cell.

Jungmoo Huh, Eun Jin Park, Jae Hyun Lee, Chan-Woong Park, Tae-Jin Yang, Won Keun Oh, Young-Won Chin

Abstract read
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Article in Journal of natural medicines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jungmoo HuhNatural Product Research Institute and Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea.ORCID http://orcid.org/0000-0002-9825-2964
Eun Jin ParkResearch Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea.ORCID http://orcid.org/0000-0002-5478-2074
Jae Hyun LeeNatural Product Research Institute and Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea.
Chan-Woong ParkNatural Product Research Institute and Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea.
Tae-Jin YangDepartment of Plant Science, Plant Genomics and Breeding Institute and Research Institute of Agriculture and Life Sciences, College of Agriculture and Life Sciences, Seoul National University, Seoul, 08826, Republic of Korea.ORCID http://orcid.org/0000-0002-9676-8801
Won Keun OhResearch Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea.ORCID http://orcid.org/0000-0003-0761-3064
Young-Won ChinNatural Product Research Institute and Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea. ywchin@snu.ac.kr.ORCID http://orcid.org/0000-0001-6964-1779

Funding

National Research foundation of korea NRF-2022R1A2C1010084National Research Foundation of Korea RS-2024-00410675
6 · The paper itself

Abstract

Two new abietane-type diterpenoids, 6β-(3-furoyloxy)ferruginol (1) and 6-chloro-6,7-dehydroferruginol (2), were isolated from the roots of Euonymus hamiltonianus along with five known diterpenoids (3-7). Their structures were characterized using various spectroscopic analysis including HRMS, 1D and 2D NMR, and ECD analysis. All isolated compounds (1-7) were evaluated for their cytotoxic activity against human colon cancer cell line, HCT116, and it was found to exhibit moderate cytotoxic activity with IC

Indexed as

AbietanesAntineoplastic Agents, PhytogenicDiterpenesEuonymusPlant ExtractsPlant RootsCell Line, TumorHCT116 CellsHumansMolecular StructureAbietanesAntineoplastic Agents, PhytogenicDiterpenesPlant ExtractsAbietane diterpeneCelastraceaeChlorinatedCytotoxicityEuonymus hamiltonianusHCT116

Identifiers

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.