Evidence map›Paper›PMID 40024960›Full record

ArticleDigestive diseases and sciences2025

An Esophageal Luminal Diameter of 16 mm Predicts Dysphagia Resolution in Eosinophilic Esophagitis.

Claire A Beveridge, Christina Hermanns, Shivani Thanawala, Qijun Yang, Yi Qin, Prashanthi N Thota, Matthew Hoscheit, J Mark Brown, Andrei I Ivanov, Anthony Lembo and 2 more

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Article in Digestive diseases and sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Claire A BeveridgeDepartment of Gastroenterology, Hepatology and Nutrition, Cleveland Clinic, Digestive Diseases Institute, Cleveland, OH, USA. beveric@ccf.org.
Christina HermannsDepartment of Internal Medicine, Cleveland Clinic, Community Care Institute, Cleveland, OH, USA.
Shivani ThanawalaDivision of Gastroenterology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Qijun YangDepartment of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA.
Yi QinDepartment of Gastroenterology, Hepatology and Nutrition, Cleveland Clinic, Digestive Diseases Institute, Cleveland, OH, USA.
Prashanthi N ThotaDepartment of Gastroenterology, Hepatology and Nutrition, Cleveland Clinic, Digestive Diseases Institute, Cleveland, OH, USA.
Matthew HoscheitDepartment of Gastroenterology, Hepatology and Nutrition, Cleveland Clinic, Digestive Diseases Institute, Cleveland, OH, USA.
J Mark BrownDepartment of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.
Andrei I IvanovDepartment of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.
Anthony LemboDepartment of Gastroenterology, Hepatology and Nutrition, Cleveland Clinic, Digestive Diseases Institute, Cleveland, OH, USA.
Scott GabbardDepartment of Gastroenterology, Hepatology and Nutrition, Cleveland Clinic, Digestive Diseases Institute, Cleveland, OH, USA.
Florian RiederDepartment of Gastroenterology, Hepatology and Nutrition, Cleveland Clinic, Digestive Diseases Institute, Cleveland, OH, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

GOALS AND

backgroundEosinophilic Esophagitis (EoE) is a chronic inflammatory esophageal disorder, often complicated by strictures requiring dilation. There is limited information on the target esophageal luminal diameter (ELD) post-treatment to relieve symptoms. The aim of this study was to determine the ELD threshold associated with dysphagia resolution in EoE patients in histologic remission. STUDY: We performed a retrospective cohort study of adult EoE patients with a stricture in histologic remission. Patients were excluded if symptoms, EoE endoscopic reference score (EREFS), and ELD were missing. ELD was estimated by dilator diameter, endoscope passage, or functional lumen imaging probe. Symptoms, demographics, EREFS, and histology were recorded. Univariate and multivariable logistic regression analyses were performed. The ELD threshold for dysphagia was determined using receiver operating characteristics analyses.

resultsOf the 76 patients who met criteria, 63 (82.9%) reported dysphagia. For every one-millimeter decrease in ELD, there was an increased odds of having dysphagia (OR 9.12, 95% CI 33.4, p < 0.001). The threshold ELD for having dysphagia was less than 16 mm (sensitivity: 96.8%, specificity: 92.3%). In a subcohort analysis of patients who were dilated (n = 58, 76.3%), the main predictor for persistent dysphagia post-dilation was the pre-dilation ELD (aOR 0.77, 95% CI 0.65-0.87, p < 0.001).

conclusionA decrease in ELD is associated with a higher odds of dysphagia in EoE patients in histologic remission. ELD of 16 mm or greater provided the strongest threshold for which symptoms were absent. This may present a reasonable dilation target.

Indexed as

Deglutition DisordersEosinophilic EsophagitisEsophageal StenosisEsophagusAdultDilatationEsophagoscopyFemaleHumansMaleMiddle AgedPredictive Value of TestsRetrospective StudiesDilationEosinophilic EsophagitisEsophageal narrowingStenosisStricture

Identifiers

PMID40024960
PMCPMC12125111

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