Evidence map›Paper›PMID 40024915›Full record

ArticlePediatric radiology2025

Significance of left ventricular strain in cardiac magnetic resonance for short-term prognosis in pediatric patients with acute lymphoblastic leukemia.

Wenfeng Jin, Yang Jia, Yi Liao, Linjun Xie, Xiangao Lei, Yingkun Guo, Lini Liu, Yilei Wang, Zhigang Yang, Chao Lin and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Wenfeng JinDepartment of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University, No. 1416, Section 1, Chenglong Avenue, Chengdu, 610000, China.
Yang JiaDepartment of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University, No. 1416, Section 1, Chenglong Avenue, Chengdu, 610000, China.
Yi LiaoDepartment of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University, No. 1416, Section 1, Chenglong Avenue, Chengdu, 610000, China.
Linjun XieDepartment of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University, No. 1416, Section 1, Chenglong Avenue, Chengdu, 610000, China.
Xiangao LeiDepartment of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University, No. 1416, Section 1, Chenglong Avenue, Chengdu, 610000, China.
Yingkun GuoDepartment of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University, No. 1416, Section 1, Chenglong Avenue, Chengdu, 610000, China.
Lini LiuDepartment of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University, No. 1416, Section 1, Chenglong Avenue, Chengdu, 610000, China.
Yilei WangDepartment of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University, No. 1416, Section 1, Chenglong Avenue, Chengdu, 610000, China.
Zhigang YangDepartment of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University, No. 1416, Section 1, Chenglong Avenue, Chengdu, 610000, China.
Chao LinDepartment of hematology, West China Second University Hospital, Sichuan University, No. 1416, Section 1, Chenglong Avenue, Chengdu, 610000, China. 174447839@qq.com.
Rong XuDepartment of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University, No. 1416, Section 1, Chenglong Avenue, Chengdu, 610000, China. Xrongdoctor@163.com.

Funding

1•3•5 project for disciplines of excellence, West China Hospital, Sichuan University ZYGD18019, ZYGD18013Chengdu Science and Technology Program 2022-GH03-00011-HZClinical Research Finding of Chinese Society of Cardiovascular Disease HFCSC2019B01Fundamental Research Funds for the Central Universities SCU2020D4132National Natural Science Foundation of China 81971586, 82071874, 82120108015, 82102020, 82271981, 82402249Sichuan Provincial Science and Technology Support Program 2020YJ0029, 21ZDYF1967, 2023YFS0020, 2021YFS0175, 2023YFQ0095Sichuan Science and Technology Youth Program 25QNJJ1963
6 · The paper itself

Abstract

backgroundThe survival rate of pediatric leukemia patients has remarkably increased. Early identification of cardiotoxicity associated with chemotherapy and the detection of prognostic factors are essential for effective patient management.

objectiveTo evaluate the prognostic value of parameters assessed by cardiac magnetic resonance imaging (MRI) in pediatric patients with acute lymphoblastic leukemia (ALL). MATERIALS AND

methodsA total of 217 children diagnosed with ALL (study group) and 65 healthy (control group) were recruited for the study and underwent cardiac MRI. Follow-up was conducted after the cardiac MRI to monitor adverse clinical events and adverse cardiac events. Cox and Kaplan-Meier (K-M) analyses were used to investigate the predictive value of cardiac MRI parameters.

resultsAll strain parameters including global radial strain, global circumferential strain, and global longitudinal strain were significantly lower in the study group compared to the control group. Global radial strain (hazard ratio (HR) = 0.89; 95% confidence interval (CI) 0.79-0.99) and global longitudinal strain (HR = 1.31; 95% CI 1.01-1.71) were indicators of adverse clinical outcomes (P < 0.05). Left ventricular remodeling index (LVRI, HR = 1.11; 95% CI 1.00-1.23) was the risk predictor for adverse cardiac events (P < 0.05). Patients with global longitudinal strain of < 18% had worse clinical outcomes (HR = 6.97, 95% CI 1.07-62.39, P = 0.04) and higher risk of adverse cardiac events (HR = 5.94, 95% CI 1.23-28.58, P = 0.03) compared with those with global longitudinal strain of ≥ 18%.

conclusionCardiac MRI-derived parameters, including global longitudinal strain, global radial strain, and LVRI, are effective prognostic tools for predicting adverse events in children diagnosed with ALL who underwent chemotherapy with anthracyclines.

Indexed as

Magnetic Resonance ImagingMagnetic Resonance Imaging, CinePrecursor Cell Lymphoblastic Leukemia-LymphomaVentricular Dysfunction, LeftAdolescentCardiotoxicityChildChild, PreschoolFemaleHumansInfantMalePrognosisCardiotoxicityGlobal longitudinal strainLeukemiaMagnetic resonance imagingPediatrics

Identifiers

PMID40024915
PMCPMC12594650

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.