Evidence map›Paper›PMID 40024880›Full record

ArticleJournal of diabetes2025

Genetically Predicted Frailty Index Is Associated With Increased Risk of Multiple Metabolic Diseases: 175 226 European Participants in a Mendelian Randomization Study.

Hexing Wang, Haifeng Zhang, Dongliang Tang, Yinshuang Yao, Junlan Qiu, Xiaochen Shu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

6 authors.

Hexing WangDepartment of Epidemiology, School of Public Health, Suzhou Medical College of Soochow University, Suzhou, People's Republic of China.ORCID https://orcid.org/0009-0002-8814-238X
Haifeng ZhangDepartment of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, MOE Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Dongliang TangDepartment of Epidemiology, School of Public Health, Suzhou Medical College of Soochow University, Suzhou, People's Republic of China.
Yinshuang YaoDepartment of Epidemiology, School of Public Health, Suzhou Medical College of Soochow University, Suzhou, People's Republic of China.
Junlan QiuDepartment of Oncology and Hematology, Suzhou Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, People's Republic of China.
Xiaochen ShuDepartment of Epidemiology, School of Public Health, Suzhou Medical College of Soochow University, Suzhou, People's Republic of China.

Funding

a Jiangsu Natural Science Fund for Young Scholars BK20210730a Project of the Priority Academic Program Development of Jiangsu Higher Education Institutions ChinaChina Postdoctoral Science Foundation 2021M702383Scientific Research Foundation for Talented Scholars in Soochow University, China Q413900215Social development-clinical frontier technology project of science and technology department of Jiangsu province BE2018669Suzhou clinical trial institution capacity enhancement project SLT202003Suzhou medical and industrial integration collaborative innovation research project SLJ202012the National Natural Science Foundation of China 32201146the Nuclear Energy Development Project, China 2016-1295
6 · The paper itself

Abstract

backgroundA relationship between frailty index (FI) and metabolic diseases (MDs) has been reported in previous observational studies. However, the causality between them remains unclear. This study aimed to examine the causal effect of FI on MDs.

methodsWe performed a bidirectional two-sample Mendelian randomization (MR) study. A recent large-scale genome-wide association study (GWAS) provided available data associated with FI, and summary statistics on eight MDs were collected from the IEU OpenGWAS database. Inverse variance weighted (IVW) was used as the main analysis to estimate causal effects, together with MR pleiotropy residual sum and outlier (MR-PRESSO), MR-Egger, Cochran's Q test, pleiotropy test, leave-one-out method, and MR Steiger analysis were used in the sensitivity analyses.

resultsOur MR study demonstrated for the first time that elevated FI was causally associated with an increased risk of MDs including obesity (odds ratio [OR] = 1.78; 95% confidence interval [CI]: 1.17-2.70; p = 0.0075), T2DM (OR = 1.67; 95% CI: 1.24-2.24; p = 6.95 × 10

conclusionsOur findings support a causal relationship between FI and multiple MDs. This is crucial for the prevention of associated MDs in patients with frailty.

Indexed as

FrailtyMetabolic DiseasesAgedEuropeFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMendelian Randomization AnalysisPolymorphism, Single NucleotideRisk FactorsWhite Peoplefrailty indexmendelian randomizationmetabolic diseases

Identifiers

PMID40024880
PMCPMC11872387

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.