Evidence map›Paper›PMID 40024582›Full record

ArticleAmerican journal of preventive medicine2025

Association Between Ultraprocessed Food Intake and Self-Reported Arthritis.

Yanxin Zhu, Vanessa Garcia-Larsen, Sabri Bromage, Euridice Martinez-Steele, Ana Luiza Curi-Hallal, Casey M Rebholz, Mika Matsuzaki

Abstract read
In one paragraph

Article in American journal of preventive medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yanxin ZhuDepartment of International Health, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Vanessa Garcia-LarsenDepartment of International Health, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Sabri BromageCommunity Nutrition Unit, Institute of Nutrition, Mahidol University, Nakhon Pathom, Thailand; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Euridice Martinez-SteeleDepartment of Nutrition, School of Public Health, University of São Paulo, São Paulo, Brazil.
Ana Luiza Curi-HallalDepartment of International Health, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland; Departamento de Saúde Pública, Centro de Ciências da Saúde, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, Brazil.
Casey M RebholzDepartment of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland; Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, Maryland.
Mika MatsuzakiDepartment of International Health, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland; Community Nutrition Unit, Institute of Nutrition, Mahidol University, Nakhon Pathom, Thailand. Electronic address: mmatsuz2@jhu.edu.

Funding

Discovery, Replication, and Validation of Biomarkers of the DASH Diet and HypertensionR01HL153178 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI REBHOLZ, CASEY MARIE · 2021 to 2024
$3.1M
Systems Science Approaches for Reducing Youth Obesity DisparitiesK01HL165465 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Mika Matsuzaki · 2023 to 2026
$683k
NHLBI NIH HHS K01 HL165465NHLBI NIH HHS R01 HL153178
6 · The paper itself

Abstract

introductionUltraprocessed foods are typically high in fat, salt, sugar, and food additives, which may contribute to the development of arthritis. This study examined the association between ultraprocessed food intake and the presence of self-reported arthritis.

methodsThe 2001-2018 U.S. National Health and Nutrition Examination Survey data was used to analyze the association between ultraprocessed food intake and arthritis in 2025. Ultraprocessed foods were identified by applying Nova classifications to 24-hour dietary recall data and expressed as a percentage of daily total energy intake. The outcomes were self-reported physician's diagnosis of arthritis, osteoarthritis, and rheumatoid arthritis. Survey-weighted logistic regressions were conducted to analyze associations between ultraprocessed food intake and outcomes, controlling for age, gender, race/ethnicity, smoking status, health insurance status, and poverty-to-income ratio.

resultsUPFs contributed 55.2% of the daily total energy intake in the U.S. POPULATION: After adjusting for covariates, a positive association was found between daily total energy intake from ultraprocessed foods and self-reported arthritis (AOR associated with each 10-percentage point increase in intake: 1.04; 95% CI=1.02, 1.06). For the second, third, and fourth quartiles of ultraprocessed food intake, the AOR of arthritis was 1.14 (95% CI=1.04, 1.25), 1.22 (95% CI=1.10, 1.35), and 1.27 (95% CI=1.14, 1.41), respectively (p for linear trend <0.001). A positive association was also observed between ultraprocessed food intake and rheumatoid arthritis (AOR=1.05; 95% CI=1.02, 1.09) but not for osteoarthritis.

conclusionsIn this nationally representative sample of U.S. adults, higher consumption of ultraprocessed foods was associated with overall arthritis and rheumatoid arthritis.

Indexed as

ArthritisDietFood HandlingAdultAgedArthritis, RheumatoidCross-Sectional StudiesEnergy IntakeFemaleHumansMaleMiddle AgedNutrition SurveysSelf ReportUnited States

Identifiers

PMID40024582
PMCPMC12632185

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.