Evidence map›Paper›PMID 40024488›Full record

ArticleNanomedicine : nanotechnology, biology, and medicine2025

Nanogels conjugated with cell-penetrating peptide as drug delivery vehicle for treating urinary tract infections.

Humberto D Escobedo, Nicholas Zawadzki, James K A Till, Andres Vazquez-Torres, Guankui Wang, Dmitri Simberg, David J Orlicky, Joshua Johnson, Marsha K Guess, Devatha P Nair and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanomedicine : nanotechnology, biology, and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. More than an infection: the ecological puzzle of recurrent urinary tract infections.Frontiers in cellular and infection microbiology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Humberto D EscobedoDepartment of Pharmaceutical Science, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Nicholas ZawadzkiDepartment of Obstetrics and Gynecology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
James K A TillDepartment of Immunology and Microbiology, School of Medicine, University of Colorado Anschutz Campus, Aurora, CO 80045, USA.
Andres Vazquez-TorresDepartment of Immunology and Microbiology, School of Medicine, University of Colorado Anschutz Campus, Aurora, CO 80045, USA; Veterans Affairs Eastern Colorado Health Care System, Denver, CO, USA.
Guankui WangDepartment of Pharmaceutical Science, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Dmitri SimbergDepartment of Pharmaceutical Science, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
David J OrlickyDepartment of Pathology, School of Medicine, University of Colorado Anschutz Campus, Aurora, CO 80045, USA.
Joshua JohnsonDepartment of Obstetrics and Gynecology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Marsha K GuessDepartment of Obstetrics and Gynecology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Devatha P NairDepartment of Craniofacial Biology, School of Dental Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Michael J SchurrDepartment of Immunology and Microbiology, School of Medicine, University of Colorado Anschutz Campus, Aurora, CO 80045, USA. Electronic address: MICHAEL.SCHURR@CUANSCHUTZ.EDU.

Funding

Molecular determinants of oxidative stress in Salmonella pathogenesisR01AI136520 · NIAID · UNIVERSITY OF COLORADO DENVER · PI Andres Vazquez-Torres · 2018 to 2026
$3.7M
Molecular Pathogenesis of Infectious DiseasesT32AI052066 · NIAID · UNIVERSITY OF COLORADO DENVER · PI VAN DYK, LINDA F. · 2002 to 2022
$2.3M
Light-propelled dental adhesives with enhanced bonding capabilityR21DE032135 · NIDCR · UNIVERSITY OF COLORADO DENVER · PI NAIR, DEVATHA P. · 2023 to 2023
$429k
Targeted Nanogel based Therapies for Chronic Recurrent Urinary Tract InfectionsR21AI154360 · NIAID · UNIVERSITY OF COLORADO DENVER · PI SCHURR, MICHAEL JOHN · 2020 to 2021
$408k
BLRD VA I01 BX002073BLRD VA IK6 BX005384NIAID NIH HHS R01 AI136520NIAID NIH HHS R21 AI154360NIAID NIH HHS T32 AI052066NIDCR NIH HHS R21 DE032135
6 · The paper itself

Abstract

Among hospital-acquired infections, Pseudomonas aeruginosa-associated urinary tract infections (UTIs) are mainly caused by indwelling urethral catheters (catheter-associated UTIs or CAUTIs) and are difficult to treat, resulting in high rates of morbidity among hospitalized patients. While antibiotics can successfully treat bacteria in the bladder lumen, they are inefficient at crossing stratified urothelium plasma membranes to kill persistent intracellular bacterial communities (IBCs). Herein, we introduce an approach to target UTI IBCs by locally delivering the antibiotic gentamicin via polymeric nanogels conjugated with a cell-penetrating peptide Cys-Gly-Lys-Arg-Lys. This novel approach delivered ~36 % more intracellular gentamicin compared to drug delivered in solution in vitro. In an acute UTI murine model, the nanogel cell-penetrating peptide drug delivery system facilitated the transport of gentamicin into the urothelium and resulted in >90 % clearance of a uropathogenic P. aeruginosa clinical strain in vivo.

Indexed as

Anti-Bacterial AgentsCell-Penetrating PeptidesDrug Delivery SystemsGentamicinsPseudomonas InfectionsUrinary Tract InfectionsAnimalsFemaleHumansMiceNanogelsPseudomonas aeruginosaAnti-Bacterial AgentsCell-Penetrating PeptidesGentamicinsNanogelsCell penetrating peptideDrug deliveryNanogelUrinary tract infection

Identifiers

PMID40024488
PMCPMC12090905

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.