ArticleJournal of neuroscience methods2025
The 3D Vertical Maze: A new model system for studying the interactions between social and spatial cognition.
Article in Journal of neuroscience methods, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
backgroundEvolutionary biology and neuroscience evidence supports the theory that spatial cognition and social cognition share neural mechanisms. Although rodent models are widely used to study either spatial or social cognition, few studies have explored the interactions between these domains, possibly because measures across tasks differ. NEW
methodWe introduce the automated 3-dimensional Vertical Maze (VM), a new model system designed to measure multiple aspects of spatial and social behavior and cognition. The VM features a standard 3-chamber maze positioned above three-level columns allowing for presentation of conspecifics as either demonstrators or discriminative stimuli at different spatial distances and different social familiarity levels. The presentation of demonstrators below the perforated floors of the 3-chamber level encourages rats to use multisensory cues to judge distance, direction, and social identity of conspecifics.
resultsUsing the VM, we found that rats showed normal social preferences whether demonstrators were presented at the near, middle, or far distance. In an operant spatial distance discrimination task, rats readily learned to associate a reward with the spatial distance of a demonstrator. COMPARISON WITH EXISTING
methodsThis new paradigm advances the field by permitting the presentation of social information (conspecifics) at different spatial distances allowing more direct comparison of behavioral measures across social and spatial information domains.
conclusionsThe VM is an effective tool for studying both spatial and social cognition opening new avenues for investigating the neural and cognitive foundations of spatial and social behavior and for exploring the possibility of shared mechanisms across these cognitive domains.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.