ReviewCurrent opinion in structural biology2025
Structural insights into the recognition of native nucleosomes by pioneer transcription factors.
Review in Current opinion in structural biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Distinct associations of pioneer factor Ascl1-E12a with nucleosomes drive changes in cell fate.Molecular cell · 2026Article
- BPabZIP, a new bZIP protein motif that promotes binding near, and displacement of, nucleosomes.bioRxiv : the preprint server for biology · 2026Article
- H2A.Z facilitates Sox2-nucleosome interaction by promoting DNA and histone H3 tail mobility.Nucleic acids research · 2026Article
- Basis for lineage-determining pioneer factors targeting distinct repressed chromatin states.Science advances · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
Abstract
Pioneer transcription factors possess the unique ability to bind to nucleosomal DNA and locally open closed chromatin, enabling the binding of additional chromatin-associated factors. These factors are pivotal in determining cell fate. Structural studies of pioneer transcription factors interacting with nucleosomes have predominantly relied on model systems incorporating canonical DNA motifs within synthetic, strongly positioned DNA. However, recent advances have revealed structures of several pioneer transcription factors bound to their native nucleosome targets at gene enhancers involved in cell reprogramming. These findings offer fresh insights into how pioneer transcription factors recognize and disrupt compact chromatin. In this review, we summarize these recent discoveries and explore their broader implications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.