ArticleThe Journal of pharmacology and experimental therapeutics2025
Elesclomol rescues mitochondrial copper deficiency in disease models without triggering cuproptosis.
Article in The Journal of pharmacology and experimental therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Effects of Dietary Copper Deficiency on Colonic Barrier Integrity, Inflammatory Markers, and Gut Microbiota Composition in Mice.Nutrients · 2026Article
- Concerns regarding the safety and efficacy of ES-Cu-Captisol for Menkes disease. Reply.The Journal of clinical investigation · 2026Article
- A C. elegans model of copper deficiency: Dietary interventions rescue CTR1/CHCA-1 copper transporter mutant phenotype.PLoS genetics · 2026Article
- Elesclomol-copper therapy improves neurodevelopment in two children with Menkes disease.The Journal of clinical investigation · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Copper (Cu) is an essential cofactor for metalloenzymes such as cytochrome c oxidase (CcO), the terminal enzyme of the mitochondrial electron transport chain. Mutations that directly or indirectly prevent Cu transport to mitochondria result in lethal pediatric diseases, such as Menkes disease. There is no clinically approved treatment for Menkes disease. We recently discovered that an investigational chemotherapy drug, elesclomol (ES), when complexed with Cu (ES-Cu), rescues mitochondrial Cu deficiency, activates CcO, and prevents perinatal lethality in a mouse model of Menkes disease. However, ES-Cu also has the potential to trigger cuproptosis, a type of Cu-dependent cell death. Therefore, to develop ES-Cu as a therapeutic agent for Menkes disease, it is critical to determine the therapeutic index of ES-Cu in Cu-deficient models. To this end, we used a Cu-deficient rat cardiomyocyte cell line and a mottled-brindled mouse model of severe Menkes disease to determine the toxicity and efficacy of ES-Cu. Our cell culture studies demonstrated that the EC
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