Evidence map›Paper›PMID 40023532›Full record

ArticleFungal biology2025

A Cryptococcus neoformans polysaccharide conjugate vaccine made with filtered polysaccharide elicits protective immunity in mice.

Piotr R Stempinski, Paola Ramos Irizarry, Scott A McConnell, Livia C Liporagi Lopes, Samuel Rodrigues Dos Santos Júnior, Maggie P Wear, Arturo Casadevall

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Fungal biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Cryptococcus.Current biology : CB · 2025
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Piotr R StempinskiDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Electronic address: pstempi1@jh.edu.
Paola Ramos IrizarryDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, USA.
Scott A McConnellDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Livia C Liporagi LopesDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Samuel Rodrigues Dos Santos JúniorDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Maggie P WearDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Arturo CasadevallDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

Funding

Conjugate vaccines for prevention and treatment of cryptococcosis - COVID-19 Revision SupplementR01AI152078 · NIAID · JOHNS HOPKINS UNIVERSITY · PI CASADEVALL, ARTURO · 2020 to 2024
$5.1M
NIAID NIH HHS R01 AI152078
6 · The paper itself

Abstract

Diseases caused by the encapsulated fungus Cryptococcus neoformans are major causes of mortality and morbidity in immunocompromised patients. Two important cryptococcal virulence factors are the polysaccharide capsule (CPS) and the secreted exopolysaccharides (EPS), both of which contain predominantly glucuronoxylomannan (GXM) polymers. Here, we evaluated the efficacy of an experimental glycoconjugate vaccine generated by linking minimally processed cryptococcal EPS with the protein carrier CRM

Indexed as

CryptococcosisCryptococcus neoformansFungal PolysaccharidesFungal VaccinesPolysaccharidesAdjuvants, ImmunologicAdjuvants, VaccineAnimalsAntibodies, FungalDisease Models, AnimalFemaleMacrophagesMiceMice, Inbred BALB CSurvival AnalysisVaccines, ConjugateAdjuvants, ImmunologicAdjuvants, VaccineAntibodies, FungalFungal PolysaccharidesFungal VaccinesglucuronoxylomannanPolysaccharidesVaccines, ConjugateCryptococcus neoformansFungal vaccineVaccine

Identifiers

PMID40023532
PMCPMC13316834

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.