ArticleAmerican journal of obstetrics and gynecology2025
Funisitis increases the risk of death or cerebral palsy in extremely preterm infants.
Article in American journal of obstetrics and gynecology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Histologic chorioamnionitis and fat mass accretion in infants born preterm.Pediatric research · 2026Article
- Infants ≤24 weeks are not just smaller extremely preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2026Review
- Severity of punctate white matter lesions in preterm infants: antecedents and cerebral palsy prediction.Pediatric research · 2025Article
- Benchmarking pathology foundation models for non-neoplastic pathology in the placenta.medRxiv : the preprint server for health sciences · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundThe relationship between histological chorioamnionitis (inflammation of fetal membranes) and funisitis (inflammation of umbilical cord), both commonly associated with preterm birth, with subsequent development of cerebral palsy remains controversial.
objectiveTo determine if extremely preterm infants (<27 weeks) exposed to histological chorioamnionitis or funisitis are at a higher risk of death or cerebral palsy compared to those without these exposures. STUDY
designMulticenter cohort study of prospectively collected data of preterm infants in the National Institute of Child Health and Development Neonatal Research Network. Infants born 2012 to 2019 who were 22 to 26 MAIN OUTCOMES AND MEASURES: The primary outcome was the composite outcome of death or cerebral palsy defined by the Amiel-Tison standardized exam and Gross Motor Function Classification System ≥1 at 22 to 26 months corrected age.
resultsA total of 6949 infants met the eligibility criteria. Of these, 3971 (57%) infants had histological chorioamnionitis, and 2978 (43%) did not have histological chorioamnionitis. About 90% (6248/6949) of infants had follow-up and complete cerebral palsy data. Similarly, 1057 (28%) infants had funisitis, and 2689 (72%) did not have funisitis. Of these, primary outcome data were available for 87% (3267/3746) infants. On multivariable analysis, histological chorioamnionitis was not associated with death or cerebral palsy (relative risk: 0.98 [95% confidence interval: 0.91, 1.05]). Exposure to funisitis was associated with a higher risk of death or cerebral palsy (relative risk: 1.09 [1.01, 1.21]) that was primarily mediated by preterm birth. There was a higher risk of cerebral palsy among surviving infants exposed to funisitis (relative risk: 1.23 [1.04, 1.51]) compared to those without funisitis. This association was partially (40%) mediated by preterm birth (relative risk: 1.08 [1.05, 1.12]), but the major effect (60%) appears to be a direct adverse effect of funisitis exposure on cerebral palsy development (relative risk: 1.13 [0.97, 1.40]).
conclusionFunisitis was associated with an increased risk of the combined outcome of death or cerebral palsy. In surviving infants, the direct adverse effects of funisitis appear to lead to cerebral palsy, independent of preterm birth.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.