Evidence map›Paper›PMID 40023338›Full record

ArticleToxicology in vitro : an international journal published in association with BIBRA2025

Cross-species comparisons of plasma binding and considerations for data evaluation.

Scott G Lynn, Irvin R Schultz, Sharlene R Matten, Purvi R Patel, Scott L Watson, Yun Lan Yueh, Sherry R Black, Barbara A Wetmore

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology in vitro : an international journal published in association with BIBRA, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Scott G LynnUS Environmental Protection Agency, Office of Pesticide Programs, William Jefferson Clinton Building, 1200 Pennsylvania Avenue NW, Washington, DC 20460, USA. Electronic address: lynn.scott@epa.gov.
Irvin R SchultzEnvironmental and Fisheries Sciences Division, Northwest Fisheries Science Center, National Marine Fisheries Service, National Oceanic and Atmospheric Administration, 2725 Montlake Boulevard East, Seattle, WA 98112, USA. Electronic address: irvin.schultz@noaa.gov.
Sharlene R MattenUS Environmental Protection Agency, Office of Program Support, William Jefferson Clinton Building, 1200 Pennsylvania Avenue NW, Washington, DC 20460, USA. Electronic address: matten.sharlene@epa.gov.
Purvi R PatelRTI International, Discovery Sciences, 3040 East Cornwallis Road, Research Triangle Park, NC 27709, USA. Electronic address: ppatel@rti.org.
Scott L WatsonRTI International, Discovery Sciences, 3040 East Cornwallis Road, Research Triangle Park, NC 27709, USA. Electronic address: slwatson@rti.org.
Yun Lan YuehRTI International, Discovery Sciences, 3040 East Cornwallis Road, Research Triangle Park, NC 27709, USA. Electronic address: yly@rti.org.
Sherry R BlackRTI International, Discovery Sciences, 3040 East Cornwallis Road, Research Triangle Park, NC 27709, USA. Electronic address: sherryb@rti.org.
Barbara A WetmoreUS Environmental Protection Agency, Office of Research and Development, Center for Computational Toxicology and Exposure, 109 T.W. Alexander Drive, Research Triangle Park, NC 27711, USA. Electronic address: wetmore.barbara@epa.gov.

Funding

Intramural EPA EPA999999
6 · The paper itself

Abstract

The US Environmental Protection Agency is increasingly employing new approach methods (NAMs), including in vitro plasma binding and hepatocyte clearance experiments to collect chemical-species specific data. This paper presents data from plasma binding experiments using rapid equilibrium dialysis (RED) devices and plasma from humans, rats, and rainbow trout with a 4-h incubation time. A total of 54 chemicals, utilizing two concentrations, were tested across the three species resulting in 238 chemical-species specific datasets. Mass balance controls for chemical plasma stability and dialysis system recovery were used to evaluate the datasets and almost 40 % of the datasets (92/238 datasets) produced quantitative measurements. Cross-species comparisons and evaluations of the impact of physicochemical properties on chemical-assay performance were also evaluated. Comparisons of human-rat plasma binding revealed rat plasma generally demonstrated higher f

Indexed as

PlasmaAnimalsDialysisHumansOncorhynchus mykissProtein BindingRatsSpecies SpecificityData evaluation frameworkHumanIn vitro-in vivo extrapolation (IVIVE)New approach methods (NAMs)Rainbow troutRatToxicokinetics

Identifiers

PMID40023338
PMCPMC12933518

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.