Evidence map›Paper›PMID 40023173›Full record

ReviewThe Lancet. Public health2025

Towards opioid access without excess.

William E Rosa, Felicia Marie Knaul, Michael Touchton, Afsan Bhadelia, Keith Humphreys, Lukas Radbruch, M R Rajagopal

Abstract readReview
In one paragraph

Review in The Lancet. Public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Hederagenin Attenuates Morphine Addiction via GABAA1-Mediated Modulation of CaAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  4. Observational
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

William E RosaDepartment of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address: rosaw@mskcc.org.
Felicia Marie KnaulDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; Institute for Advanced Study of the Americas, University of Miami, Coral Gables, FL, USA; Escuela de Medicina y Ciencias de la Salud, Technológico de Monterray Faculty of Excellence, Mexico City, Mexico; Tómatelo a Pecho, Asociación Civil, Mexico City, Mexico.
Michael TouchtonInstitute for Advanced Study of the Americas, University of Miami, Coral Gables, FL, USA; Department of Political Science, College of Arts and Sciences, University of Miami, Miami, FL, USA.
Afsan BhadeliaInstitute for Advanced Study of the Americas, University of Miami, Coral Gables, FL, USA; Department of Public Health, College of Health and Human Sciences, Purdue University, West Lafayette, IN, USA.
Keith HumphreysDepartment of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA, USA; Center for Innovation to Implementation, Veterans Affairs Health Care System, Palo Alto, CA, USA.
Lukas RadbruchDepartment of Palliative Medicine, University of Bonn, Bonn, Germany; International Association for Hospice & Palliative Care, Houston, TX, USA.
M R RajagopalTrivandrum Institute of Palliative Sciences, Thiruvanthapuram, Kerala, India; Department of Palliative Care, Pallium India, Thiruvanthapuram, Kerala, India.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

A decade after World Health Assembly Resolution 67.19 recognised palliative care as a component of comprehensive care and universal health coverage throughout the life course, a balanced approach to opioid access remains elusive. Disparities in the alleviation of serious health-related suffering persist, characterised by two parallel opioid-related public health crises: a pandemic of unrelieved pain and an opioid addiction epidemic. The pain pandemic is largely driven by the opioid access abyss and primarily affects over 50 million people with serious health-related suffering living in low-income and middle-income countries. Conversely, several high-income countries have been affected by an opioid addiction epidemic. An estimated 39·5 million people struggle with opioid use disorder worldwide, the vast majority living in North America. In this Viewpoint, we describe these parallel crises, argue for pain relief as a global public good, and identify stewardship roles of WHO member states and local actors to use a balanced approach in galvanising the global health system to simultaneously close the global pain divide and move towards opioid access without excess in alignment with Sustainable Development Goal targets focused on the prevention of substance abuse (3.5) and universal health coverage (3.8).

Indexed as

Analgesics, OpioidHealth Services AccessibilityOpioid-Related DisordersGlobal HealthHumansOpioid EpidemicAnalgesics, Opioid

Identifiers

PMID40023173
PMCPMC12145491

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.