Evidence map›Paper›PMID 40023156›Full record

ArticleImmunity2025

Collaboration between interleukin-7 and -15 enables adaptation of tissue-resident and circulating memory CD8

Nicholas N Jarjour, Talia S Dalzell, Nicholas J Maurice, Kelsey M Wanhainen, Changwei Peng, Stephen D O'Flanagan, Taylor A DePauw, Katharine E Block, William J Valente, K Maude Ashby and 2 more

Abstract read
In one paragraph

Article in Immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
  2. Monocyte-derived galectin-1Nature immunology · 2026
    Article
  3. Article
  4. Article
  5. IL-15/NKG2D signaling-mediated activation of CD8Journal of thoracic disease · 2026
    Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Evolving role of CD8Frontiers in immunology · 2026
    Review
  16. Metabolic Checkpoints in CD8International journal of biological sciences · 2026
    Review
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Nicholas N JarjourCenter for Immunology, University of Minnesota, Minneapolis, MN 55455, USA; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: njarjour@umn.edu.
Talia S DalzellCenter for Immunology, University of Minnesota, Minneapolis, MN 55455, USA; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA.
Nicholas J MauriceCenter for Immunology, University of Minnesota, Minneapolis, MN 55455, USA; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA.
Kelsey M WanhainenCenter for Immunology, University of Minnesota, Minneapolis, MN 55455, USA; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA.
Changwei PengCenter for Immunology, University of Minnesota, Minneapolis, MN 55455, USA; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA.
Stephen D O'FlanaganCenter for Immunology, University of Minnesota, Minneapolis, MN 55455, USA; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN 55455, USA.
Taylor A DePauwCenter for Immunology, University of Minnesota, Minneapolis, MN 55455, USA; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA.
Katharine E BlockCenter for Immunology, University of Minnesota, Minneapolis, MN 55455, USA; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA.
William J ValenteCenter for Immunology, University of Minnesota, Minneapolis, MN 55455, USA; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA.
K Maude AshbyCenter for Immunology, University of Minnesota, Minneapolis, MN 55455, USA; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA.
David MasopustCenter for Immunology, University of Minnesota, Minneapolis, MN 55455, USA; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN 55455, USA.
Stephen C JamesonCenter for Immunology, University of Minnesota, Minneapolis, MN 55455, USA; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: james024@umn.edu.

Funding

T Cell HomeostasisR01AI038903 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI STEPHEN C JAMESON · 2001 to 2026
$5.9M
IMMUNOLOGY TRAINING PROGRAMT32AI007313 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Carla Rothlin · 1989 to 2026
$5.7M
Profiling and leveraging bystander T cells within the tumor microenvironmentK00CA245735 · NCI · UNIVERSITY OF MINNESOTA · PI MAURICE, NICHOLAS JOSEPH · 2022 to 2025
$372k
Paving the way for bystander T cell immunotherapiesK99CA296729 · NCI · UNIVERSITY OF MINNESOTA · PI NICHOLAS JOSEPH MAURICE · 2025 to 2026
$228k
Cytokine regulation of recirculating and tissue-resident memory CD8+ T cells in homeostasis and inflammationK22AI177360 · NIAID · VERSITI BLOOD HEALTH, INC. · PI Nicholas N Jarjour · 2025 to 2026
$203k
Role of P2RX7 in making CD8+ T cells for tumor immunotherapy.F30CA250321 · NCI · UNIVERSITY OF MINNESOTA · PI WANHAINEN, KELSEY · 2020 to 2023
$161k
Investigating the Abundance, Fate, and Function of Secondary Lymphoid Organ Resident Memory T cellsF31AI176750 · NIAID · UNIVERSITY OF MINNESOTA · PI O'FLANAGAN, STEPHEN D · 2023 to 2024
$69k
NCI NIH HHS F30 CA250321NCI NIH HHS K00 CA245735NCI NIH HHS K99 CA296729NIAID NIH HHS F31 AI176750NIAID NIH HHS K22 AI177360NIAID NIH HHS R01 AI038903NIAID NIH HHS T32 AI007313
6 · The paper itself

Abstract

Interleukin-7 (IL-7) is considered a critical regulator of memory CD8

Indexed as

CD8-Positive T-LymphocytesImmunologic MemoryInterleukin-15Interleukin-7Memory T CellsAnimalsCell ProliferationHomeostasisMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicReceptors, Interleukin-7Signal TransductionInterleukin-15Interleukin-7interleukin-7 receptor, alpha chainReceptors, Interleukin-7adaptive immunityCD8(+) T cellsimmune memoryinterleukin-15interleukin-7interleukin-7 receptor αmemory homeostasisproliferation

Identifiers

PMID40023156
PMCPMC13329436

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.