ArticleNeuroImage. Clinical2025
Event-related potential markers of subjective cognitive decline and mild cognitive impairment during a sustained visuo-attentive task.
Article in NeuroImage. Clinical, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Independent component analysis of brain network alterations associated with cognitive impairment in coal workers' pneumoconiosis.BMC medical imaging · 2026Article
- Differences in event-related potentials between unipolar depression and bipolar II disorder during depressive episodes: a retrospective case-control study.BMC psychiatry · 2025Article
- Digital twins and non-invasive recordings enable early diagnosis of Alzheimer's disease.Alzheimer's research & therapy · 2025Observational
- Personalized brain models link cognitive decline progression to underlying synaptic and connectivity degeneration.Alzheimer's research & therapy · 2025Article
- Article
- Association of cognitive function with frailty, nutritional status, and quality of life in older adults with mild cognitive impairment.PloS one · 2025Article
- EEG recordings during visuo-attentive task reduce sex bias in Alzheimer's disease diagnosis.Alzheimer's & dementia (New York, N. Y.)Article
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Authors and funding
21 authors.
Funding
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Abstract
Subjective cognitive decline (SCD), mild cognitive impairment (MCI), and Alzheimer's disease stages lack well-defined electrophysiological correlates, creating a critical gap in the identification of robust biomarkers for early diagnosis and intervention. In this study, we analysed event-related potentials (ERPs) recorded during a sustained visual attention task in a cohort of 178 individuals (119 SCD, 40 MCI, and 19 healthy subjects, HS) to investigate sensory and cognitive processing alterations associated with these conditions. SCD patients exhibited significant attenuation in both sensory (P1, N1, P2) and cognitive (P300, P600, P900) components compared to HS, with cognitive components showing performance-related gains. In contrast, MCI patients did not show a further decrease in any ERP component compared to SCD. Instead, they exhibited compensatory enhancements, reversing the downward trend observed in SCD. This compensation resulted in a non-monotonic pattern of ERP alterations across clinical conditions, suggesting that MCI patients engage neural mechanisms to counterbalance sensory and cognitive deficits. These findings support the use of electrophysiological markers in support of medical decision-making, enhancing personalized prognosis and guiding targeted interventions in cognitive decline.
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