Evidence map›Paper›PMID 40023005›Full record

ArticleSchizophrenia research2025

Building a two-state learning healthcare system for persons with first episode psychosis.

Jill A Marsteller, Richard W Goldberg, Yasmine Boumaiz, Megan B E Jumper, Jessica Taylor, Arunadevi Saravana, Robert W Buchanan, K N Roy Chengappa, Catherine G Conroy, Faith Dickerson and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Schizophrenia research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Jill A MarstellerDepartment of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Electronic address: Jmarste2@jhu.edu.
Richard W GoldbergDepartment of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
Yasmine BoumaizDepartment of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
Megan B E JumperPennsylvania Early Intervention Center (PEIC)/HeadsUp, Neurodevelopment and Psychosis Section, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Neurodevelopment and Psychosis Section, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Jessica TaylorDepartment of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
Arunadevi SaravanaDepartment of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
Robert W BuchananMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
K N Roy ChengappaDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Catherine G ConroyPennsylvania Early Intervention Center (PEIC)/HeadsUp, Neurodevelopment and Psychosis Section, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Neurodevelopment and Psychosis Section, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Faith DickersonDepartment of Psychology, Sheppard Pratt, Baltimore, MD, USA.
Arielle EredPennsylvania Early Intervention Center (PEIC)/HeadsUp, Neurodevelopment and Psychosis Section, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Neurodevelopment and Psychosis Section, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Nev JonesUniversity of Pittsburgh School of Social Work, Pittsburgh, PA, USA.
Christian G KohlerPennsylvania Early Intervention Center (PEIC)/HeadsUp, Neurodevelopment and Psychosis Section, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Neurodevelopment and Psychosis Section, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Julie KreyenbuhlDepartment of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
Alicia LuckstedDepartment of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
Russell L MargolisDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Deborah MedoffDepartment of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
Peter PhalenDepartment of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
Deepak K SarpalDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
William R SmithDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Crystal VatzaPennsylvania Early Intervention Center (PEIC)/HeadsUp, Neurodevelopment and Psychosis Section, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Neurodevelopment and Psychosis Section, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Monica E CalkinsPennsylvania Early Intervention Center (PEIC)/HeadsUp, Neurodevelopment and Psychosis Section, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Neurodevelopment and Psychosis Section, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Melanie E BennettDepartment of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.

Funding

UMB Admin CoreP01MH139228 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI MELANIE E. BENNETT · 2024 to 2026
$6.3M
Improving Engagement in Black Clients Participating in Coordinated Specialty Care: A Mixed Methods Pilot StudyR01MH120550 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI BENNETT, MELANIE E. · 2020 to 2023
$5.9M
Pharmacogenetic Treatment with Anti-Glutaminergic Agents for Comorbid PTSD & AUDR01AA024760 · NIAAA · UNIVERSITY OF MARYLAND BALTIMORE · PI BENNETT, MELANIE E. · 2016 to 2020
$3.0M
Targeting Emotion Dysregulation to Reduce Suicide in People with PsychosisK23MH125024 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI PHALEN, PETER LEE · 2022 to 2025
$711k
NIAAA NIH HHS R01 AA024760NIMH NIH HHS K23 MH125024NIMH NIH HHS P01 MH139228NIMH NIH HHS R01 MH120550
6 · The paper itself

Abstract

The Connection Learning Healthcare System (CLHS) represents a network of academic institutions, state behavioral health systems, and early psychosis specialty care programs in Pennsylvania and Maryland working together to provide the best evidence-based care for persons with first episode psychosis. Developing an integrated, two-state system required unification and harmonization of data collection, training, consultation, research, and dissemination activities. Here we describe the model that supported these efforts and our experience creating an active two-state learning healthcare system. We also review areas of ongoing attention and offer lessons learned.

Indexed as

Learning Health SystemMental Health ServicesPsychotic DisordersHumansMarylandPennsylvaniaFirst episode psychosisLearning healthcare system

Identifiers

PMID40023005
PMCPMC12046522

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.