Evidence map›Paper›PMID 40022738›Full record

ArticleSTAR protocols2025

Protocol for detecting and analyzing non-oscillatory traveling waves from high-spatiotemporal-resolution human electrophysiological recordings.

Veronica M Zarr, Jyun-You Liou, Edward M Merricks, Tyler S Davis, Kyle Thomson, Bradley Greger, Paul A House, Ronald G Emerson, Robert R Goodman, Guy M McKhann and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in STAR protocols, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Veronica M ZarrNeurosurgery Department, University of Utah, Salt Lake City, UT 84117, USA. Electronic address: veronica.zarr@utah.edu.
Jyun-You LiouDepartment of Anesthesiology, Weill Cornell Medicine, New York, NY 10065, USA.
Edward M MerricksDepartment of Neurology, Columbia University, New York, NY 10032, USA.
Tyler S DavisNeurosurgery Department, University of Utah, Salt Lake City, UT 84117, USA.
Kyle ThomsonDepartment of Pharmacology & Toxicology, University of Utah, Salt Lake City, UT 84117, USA.
Bradley GregerSchool of Biological & Health Systems Engineering, Arizona State University, Tempe, AZ 85281, USA.
Paul A HouseNeurosurgical Associates, LLC, Murray, UT 84107, USA.
Ronald G EmersonHospital for Special Surgery, New York, NY 10021, USA.
Robert R GoodmanLenox Hill Hospital, New York, NY 10075, USA.
Guy M McKhannDepartment of Neurological Surgery, Columbia University, New York, NY 10032, USA.
Sameer A ShethDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX 77030, USA.
Catherine A SchevonDepartment of Neurology, Columbia University, New York, NY 10032, USA.
John D RolstonBrigham & Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Elliot H SmithNeurosurgery Department, University of Utah, Salt Lake City, UT 84117, USA; Department of Neurology, Columbia University, New York, NY 10032, USA. Electronic address: e.h.smith@utah.edu.

Funding

Seizure localization in humans: the effect of inhibitory surround on the EEGR01NS084142 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SCHEVON, CATHERINE A · 2013 to 2022
$6.0M
Training in the Development of Novel Interventions for the Treatment of Neurological and Neurobehavioral DisordersT32NS115723 · NINDS · UNIVERSITY OF UTAH · PI KEEFE, KRISTEN A · 2020 to 2024
$1.1M
Patient-Specific Modeling and Network Perturbation to Enhance the Predictability of Direct Cortical Stimulation for EpilepsyK23NS114178 · NINDS · UNIVERSITY OF UTAH · PI ROLSTON, JOHN D · 2019 to 2023
$961k
Propagation patterns of microelectrode-recorded human interictal dischargesR21NS113031 · NINDS · UNIVERSITY OF UTAH · PI ROLSTON, JOHN D · 2019 to 2019
$427k
Integrated Multiscale Data Acquisition System for Human Intracranial NeurophysiolS10OD018211 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SCHEVON, CATHERINE A · 2014 to 2014
$322k
NIH HHS S10 OD018211NINDS NIH HHS K23 NS114178NINDS NIH HHS R01 NS084142NINDS NIH HHS R21 NS113031NINDS NIH HHS T32 NS115723
6 · The paper itself

Abstract

Innovations in electrophysiological recordings and computational analytic techniques enable high-resolution analysis of neural traveling waves. Here, we present a protocol for the detection and analysis of traveling waves from multi-day microelectrode array human electrophysiological recordings through a multi-linear regression statistical approach using point estimator data. We describe steps for traveling wave detection, feature characterization, and propagation pattern analysis. This protocol may improve our understanding of the coordination of neurons during non-oscillatory neural dynamics. For complete details on the use and execution of this protocol, please refer to Smith et al.

Indexed as

Electrophysiological PhenomenaElectrophysiologyHumansMicroelectrodesNeuronsBehaviorCognitive NeuroscienceNeuroscience

Identifiers

PMID40022738
PMCPMC11919625

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.