ArticleAsian Pacific journal of cancer prevention : APJCP2025
Clinical Investigation of IL-31, TOS and GSH in the Sera of Gastric Cancer Females Patients In Iraq.
Article in Asian Pacific journal of cancer prevention : APJCP, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivethe main objective of the study intends to assessing blood levels of interleukin-31 (IL-31), Total Oxidative Stress (TOS), and Glutathione (GSH) and Understanding the relationships between these factors and gastric cancer (GC), additionally studying receiving operation characteristic analysis to understand the effect of this parameters on GC that may reveal new information about the disease's pathogenesis and suggest possible diagnostic and therapeutic strategies.
methodThe study sought to determine the concentrations of anthropometric factors (age and BMI), immunological parameters (IL-31) and parameters related to oxidative stress (TOS and GSH) in the sera of female gastric cancer females patients. The study included 80 people divided into two groups: 40 healthy participants and 40 gastric cancer patients' group, the samples were collected between January to March 2023.
resultsThere is a non-significant (p>0.05) difference in age and BMI between controls and patients. The study found a substantial increase (P<0.001) in IL-31 and TOS levels in GC females matched to controls. However, there was non-significant difference (p>0.05) in GSH levels between healthy controls and GC patients. From ROC analysis it is confirmed that TOS has the highest specificity and sensitivity among the studied parameters.
conclusionThe net result shows that there is an association among the inflammatory immunological parameter IL-31 and GC infection, and that the body's immunity system plays a significant role in fighting this disease, while also demonstrating that oxidative stress plays an important role in the regulation of the disease.
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