ArticleAsian Pacific journal of cancer prevention : APJCP2025
Evaluation of Salivary Carcinogenic microR-21 and miR-125a Expression Associated with Alcohol Consumption and Smoking.
Article in Asian Pacific journal of cancer prevention : APJCP, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Salivary miR-21 as a Lifestyle-Responsive Biomarker: A Critical Appraisal and Future Perspectives.Asian Pacific journal of cancer prevention : APJCP · 2026Article
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3 authors.
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Abstract
objectiveThe concept of "lifestyle" encompasses various factors, including nutrition, behavior, stress, physical activity, work habits, smoking, and alcohol consumption. Increasing evidence suggests that environmental and lifestyle factors can influence epigenetic mechanisms, such as DNA methylation, histone acetylation, and microRNA expression. Given that microRNAs (miRNAs) are an emerging focus in cancer research, there is growing interest in understanding how lifestyle choices affect miRNA responses. MiR-21 is well-established as an oncogenic miRNA, while miR-125a is reported as a tumor-suppressive miRNA in different cancers. This study aimed to analyze whether cigarette smoking and alcohol consumption are associated with altered levels of these salivary miRNAs in healthy individuals.
methodsSaliva supernatant samples from 50 healthy individuals (10% smokers and 34% alcohol drinkers) were analyzed alongside non-smokers and non-alcohol drinkers using real-time polymerase chain reaction (PCR). The expression levels of miR-21 and miR-125a were compared across samples based on demographic characteristics, social status, and smoking and drinking habits.
resultThe data showed overexpression of salivary miR-21 in individuals who regularly consumed alcohol and smoked, while miR-125a expression was not significantly affected in either group.
conclusionThe differential expression of salivary miR-21 in healthy individuals from a localized population suggests a correlation with common lifestyle risk factors.
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