ArticleAsian Pacific journal of cancer prevention : APJCP2025
Investigating the Anticancer Activity of Cerium Nanoparticle Decorated on GO Produced by Green Methods against Cancerous Cell Lines.
Article in Asian Pacific journal of cancer prevention : APJCP, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Structure-Biomedical Activity Relationship of Tunable Ceria-Graphene Nanocomposites Leading to Divergent Cellular Responses.International journal of molecular sciences · 2026Article
- Rare-Earth Elements at the Interface of Chemistry and Cancer Therapy.Molecules (Basel, Switzerland) · 2026Review
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5 authors.
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Abstract
introductionGreen synthesis of nanoparticles is a promising technique for creating functionalized nanoparticles (NPs) without generating byproducts, unlike chemical synthesis methods compared to traditional cancer treatments.
aimTo determine the potential impact of Graphene-Oxide/Cerium Oxide nanoparticles GO/CeO2 NPs as an anti-tumor agent in biomedical field, an in vitro study.
methodsIn the current study, CeO2 was synthesized using co-precipitation method. The method of preparation used is considered green due the usage of Allium Sativum extract in the synthesis of CeO2 nanoparticles. Graphene -Oxide (GO) was prepared by pulsed laser ablation in water (PLAL) which is also considered as a green method. The decoration of CeO2 on GO was achieved by mixing the GO with CeO2 nanocolloid, then characterized. For the in vitro study, CeO2 concentrations were used (0.98 - 250 µg/ml) as duplicate against human breast cancer cell line AMJ13, brain cancer cell line AMGM5, human esophagus cancer cell line SK-GT-4 and compared with normal cell line REF.
resultsThe FESEM results show that the CeO2 NPs are homogeneous and nearly spherical in its shape with an average dimension of 55 nm. The in vitro results showed that the GO/CeO2 had significant potential impact in the high concentration 250 µg/ml at p> 0.05 against breast cancer cell line AMJ13 (with growth inhibition 51.04%) compared with other cell lines that showed less significant effect at p> 0.05 on brain cancer cell line AMGM5 (with growth inhibition 37.12%) and increased the proliferation rate on pp cancer cell line SK-GT-4 compared with no effects on control normal cell line REF during 48 h. of time exposure.
conclusionsBased on the results, we concluded that the synthesized CeO2 is a promising tool for use as a drug delivery agent against breast cancer, demonstrating high safety for the normal REF cell line.
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