ArticleWound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
Buprenorphine blunts inflammatory response and wound progression after skin exposure to nitrogen mustard.
Article in Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Single-cell transcriptomics reveals cellular dynamics and chemokine CXCL2-mediated smooth muscle cell proliferation in arterial repair.Frontiers in immunology · 2025Article
- Buprenorphine blunts inflammatory response and wound progression after skin exposure to nitrogen mustard.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair SocietyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Opioid analgesics are often used to alleviate pain in rodent models of skin wound injury and repair. However, previous studies have demonstrated that opioids can alter the inflammatory response to injury and subsequent wound healing. The purpose of this study was to determine the impact of different formulations of buprenorphine on mouse behaviour, inflammatory response and wound progression following skin exposure to nitrogen mustard (NM). Administration of either short-acting or long-acting formulations of buprenorphine in conjunction with skin NM exposure resulted in body weight loss, reduced activity and behavioural changes. Both short-acting and long-acting formulations also dampened aspects of the inflammatory response to NM exposure, including reduced levels of the chemokines CCL3 and CXCL2 and reduced accumulation of pro-inflammatory macrophages. The diminished inflammatory response was associated with reduced skin injury assessed both externally and histologically. These results have important implications for the use of opioid analgesics in studies involving vesicant exposure as well as the potential for the use of opioids as a countermeasure after NM exposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.