Evidence map›Paper›PMID 40022597›Full record

ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2025

Gastric hypoplasia in mice lacking fibroblast growth factor 9.

Jason C Mills, Nattapon Thanintorn, Yongjun Yin, Helen McNeill, David M Ornitz, Spencer G Willet

Abstract read
In one paragraph

Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jason C MillsSection of Gastroenterology, Department of Medicine, Pathology and Immunology, and Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA.
Nattapon ThanintornDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, USA.
Yongjun YinDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, USA.
Helen McNeillDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, USA.
David M OrnitzDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0003-1592-7629
Spencer G WilletDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0002-2541-263X

Funding

Washington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Nicholas O. Davidson · 2000 to 2026
$30.8M
Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI James Versalovic · 2001 to 2026
$28.3M
REGULATION OF ATROPHY-INDUCED PROGENITOR CELLS IN THE GASTRIC CORPUSR01DK094989 · NIDDK · WASHINGTON UNIVERSITY · PI Jason C Mills · 2012 to 2026
$6.1M
FGF18 regulation of postnatal lung developmentR01HL154747 · NHLBI · WASHINGTON UNIVERSITY · PI ORNITZ, DAVID M · 2020 to 2023
$2.5M
MOLECULAR REGULATION OF GASTRIC CHIEF (ZYMOGENIC) CELL DIFFERENTIATIONR01DK079798 · NIDDK · WASHINGTON UNIVERSITY · PI MILLS, JASON C · 2008 to 2012
$1.6M
The role of the Hippo Pathway in gastric homeostasis and metaplasiaK01DK120800 · NIDDK · WASHINGTON UNIVERSITY · PI WILLET, SPENCER GAFFNEY · 2020 to 2024
$756k
NHLBI NIH HHS R01 HL154747NIDDK NIH HHS K01 DK120800NIDDK NIH HHS P30 DK052574NIDDK NIH HHS P30 DK056338NIDDK NIH HHS R01 DK079798NIDDK NIH HHS R01 DK094989
6 · The paper itself

Abstract

backgroundFibroblast Growth Factor 9 (Fgf9) and its paralog Fgf20 are expressed in the developing stomach. We investigate the role of these growth factors during gastric development, using combinations of null alleles.

resultsAnalysis of expression databases showed that Fgf9 is expressed in gastric endoderm and surrounding mesoderm such as the mesothelium as early as E8.5, and Fgf20 is expressed in the gastric progenitors of the glandular stomach. To explore whether Fgf9 and Fgf20 are important for gastric development, we examined embryonic stomachs from Fgf9 and Fgf20 null (Fgf9

conclusionsFgf9 drives gastric growth and squamous epithelial identity during gastric development.

Indexed as

Fibroblast Growth Factor 9Fibroblast Growth FactorsStomachAnimalsGastric MucosaGene Expression Regulation, DevelopmentalMiceMice, KnockoutFgf20 protein, mouseFgf9 protein, mouseFibroblast Growth Factor 9Fibroblast Growth FactorsFgf10Fgf9forestomachstomach

Identifiers

PMID40022597
PMCPMC13504712

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.