Observational studyNursing in critical care2025
Interruptions and downtime of continuous renal replacement therapy in critically ill adults: A retrospective observational study.
Observational study in Nursing in critical care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The trial behind it
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Who cites it
3 citing papers in PubMed.
- The comparison of circuit lifespan between integration and separation approach in extracorporeal membrane oxygenation patients requiring continuous renal replacement therapy support: a randomized controlled trial (E-CRRT Trial).Intensive care medicine · 2026Trial
- [Factors affecting filter lifespan in patients receiving continuous renal replacement therapy at a tertiary hospital in South Korea: a cross-sectional descriptive study].Journal of Korean biological nursing science · 2025Article
- Interruptions and downtime of continuous renal replacement therapy in critically ill adults: A retrospective observational study.Nursing in critical care · 2025Observational
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Authors and funding
9 authors.
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Abstract
backgroundThe effective treatment time of continuous renal replacement therapy (CRRT) is significantly important. Downtime caused by interruptions is still unclear during a circuit filter.
aimThis study aimed to analyse the interruptions and downtime during a circuit filter through the data recorded by the internal data storage cards of the CRRT machine.
methodsThis is a single-centre retrospective observational study. From August 2019 to April 2020, all patients who received CRRT treatment with the Prismaflex device (Gambro, America) were enrolled. After downloading the data from the internal data storage cards, it was meticulously sorted and verified using Excel. Statistical analyses were performed using SPSS software (version 22.0).
resultsA total of 143 CRRT circuits in 59 patients were analysed. The overall median circuit life was 39.22 (IQR, 24.07-60.25) h, median amount of interruption was 67 (IQR, 42-100), causing a median downtime of 1.98 (IQR, 1.20-2.85) h and a median downtime proportion (ratio of downtime/circuit life) of 4.58% (IQR, 3.50-6.69). Circuit downtime was mainly caused by bag change (1.17 ± 0.66 h [p < 0.001]). Circuits in the group of downtime proportion >10% had longer downtime (2.53 ± 3.37 h, p < 0.001) and more circuit alarms (45.54 ± 42.87, p < 0.001), and alarms cost much more time to be fixed (1.03 [IQR, 0.42-2.24] h, p < 0.001). No variation was found in downtime among groups according to circuit lifespan.
conclusionsInterruptions in a circuit can accumulate into non-negligible downtime. Specialized nursing actions through education and training are of great significance to avoid unnecessary interruptions. RELEVANCE TO CLINICAL PRACTICE: Nurses' behaviour is related to the downtime of CRRT. Intensive care unit (ICU) nurses should be trained to inculcate the behaviours, including keeping sufficient bags at patient's bedside, changing solution bags actively, adressing alarms swiftly, arranging the examinations and the initiation of a CRRT reasonably.
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