ArticleThe New phytologist2025
GCN5-related histone acetyltransferase HOOKLESS2 regulates fungal resistance and growth in tomato.
Article in The New phytologist, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Acetylation as a dynamic regulatory interface between plant stress memory, cross-tolerance, and crop resilience design.Frontiers in plant science · 2026Pooled it
- Insights Into the Role of Lysine Acetylation of Non-Histone Proteins in Plant Immunity.Plant, cell & environment · 2026Review
- Ectopic overexpression of cucumber CsBT2 gene increases drought and salt stress sensitivity in Arabidopsis.BMC plant biology · 2026Article
- Plant BTB (Broad-Complex, Tramtrack, and Bric-à-Brac) Proteins: Structural Features, Biological Functions, and Roles in Stress Responses.Plants (Basel, Switzerland) · 2026Review
- Genome-Wide Identification of Histone Acetyltransferases inJournal of fungi (Basel, Switzerland) · 2026Article
- Epigenetic Regulation of Cotton Plant Height by Histone Acetyltransferase GhHAT11 via Hormonal Pathway Modulation.Physiologia plantarumArticle
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Authors and funding
4 authors.
Funding
Abstract
The functions of histone acetyltransferases (HATs) in the genetic control of crop traits and the underlying mechanisms are poorly understood. We studied the function of tomato HOOKLESS2 (SlHLS2), a member of the GCN5 family of HATs, through genetic, molecular and genomic approaches. Tomato hls2 mutants generated through CRISPR-cas9 gene editing show enhanced susceptibility to fungal infection, accelerated dark-induced senescence, grossly altered plant architecture, and loss of fertility accompanied by high levels of auxin accumulation. Components of the basal and induced transcriptome underlying the extensive phenotypic impact of HLS2 were uncovered. HLS2-dependent differentially expressed genes were enriched for genes implicated in photosynthesis, protein ubiquitination, oxylipin biosynthesis, autophagy, and response to biotic stimuli. In particular, induced expressions of the BTB/POZ and TAZ domain-containing protein gene (SlBT1), AUTOPHAGY-RELATED PROTEIN 11, ACYLSUGAR ACYLTRANSFERASE 3 (ASAT3), and multiple jasmonate biosynthesis genes require functional HLS2. SlHLS2 associates with the SlBT1 promoter, and histone acetylation at the chromatin of SlBT1 was reduced in the Slhls2 mutant suggesting direct regulation of SlBTB1 by HLS2. SlBTB1 is an adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB), which mediates ubiquitination and proteasomal degradation of proteins. HLS2 is degraded after fungal inoculation, which is stabilized by inhibition of the 26S proteasome. Overall, tomato HLS2 functions in pathogen responses, plant architecture, and fertility.
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