Evidence map›Paper›PMID 40022464›Full record

ArticleEuropean journal of neurology2025

Cortisol and 10-Year Cognitive Decline in Older People From the General Population.

Simone Amendola, Sami Ouanes, Leonardo Zullo, Miriam Rabl, Giorgio Pistis, Enrique Castelao, Pedro Marques-Vidal, Julien Vaucher, Armin von Gunten, Martin Preisig and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Simone AmendolaDepartment of Adult Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich and University of Zurich, Zurich, Switzerland.ORCID 0000-0002-1950-4351
Sami OuanesService of Old-Age Psychiatry, Department of Psychiatry, University Hospital of Lausanne, Lausanne, Switzerland.
Leonardo ZulloDepartment of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland.ORCID 0000-0002-9279-4914
Miriam RablDepartment of Adult Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich and University of Zurich, Zurich, Switzerland.ORCID 0000-0002-3189-6554
Giorgio PistisPsychiatric Epidemiology and Psychopathology Research Center, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Enrique CastelaoPsychiatric Epidemiology and Psychopathology Research Center, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Pedro Marques-VidalDepartment of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.ORCID 0000-0002-4548-8500
Julien VaucherService of Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Armin von GuntenService of Old-Age Psychiatry, Department of Psychiatry, University Hospital of Lausanne, Lausanne, Switzerland.
Martin PreisigDepartment of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland.
Julius PoppDepartment of Adult Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich and University of Zurich, Zurich, Switzerland.ORCID 0000-0002-0068-0312

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe present study examined bidirectional effects between salivary cortisol and cognitive functioning over time. Furthermore, the role of the APOE-ɛ4 allele as a moderator of the associations was investigated.

methodsUsing a prospective population-based study, we analyzed data from 752 older adults followed up over 10 years. A random-intercept Cross-Lagged Panel Model was applied to each combination of one cortisol measure (at waking time, 30 min after waking, 11 am, 8 pm, cortisol awakening response, total daily output, and diurnal slope) and one cognitive measure (primary outcome: Clinical Dementia Rating Scale sum of boxes score, CDR-SB; secondary outcome: Mini-Mental State Examination) resulting in 14 (7 × 2) models.

resultsBetween-person effects pointed out that a higher cortisol level at 11 am was associated with increased CDR-SB scores, and a higher cortisol awakening response was associated with decreased CDR-SB scores. Within-person effects indicated that cortisol levels at 11 am and 8 pm, and total daily cortisol output were associated with subsequent lower CDR-SB scores. The APOE-ɛ4 allele did not moderate the relationship between cortisol and cognitive functioning.

conclusionsOur findings revealed within-person associations between higher cortisol levels and better cognitive functioning at the subsequent follow-up, suggesting cortisol protective effects for cognitive decline.

Indexed as

Cognitive DysfunctionHydrocortisoneAgedAged, 80 and overApolipoprotein E4FemaleHumansMaleNeuropsychological TestsProspective StudiesSalivaApolipoprotein E4Hydrocortisonecognitioncognitive declineCoLaus|PsyCoLauscortisoldementiaHPA axis

Identifiers

PMID40022464
PMCPMC11871105

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.