Evidence map›Paper›PMID 40022452›Full record

ArticleJournal of morphology2025

On the Maxillofacial Development of Mice, Mus musculus.

Hiroki Higashiyama, Shunya Kuroda, Akiyasu Iwase, Naoki Irie, Hiroki Kurihara

Abstract read
In one paragraph

Article in Journal of morphology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Three-dimensional cellular dynamics and mandibular morphogenesis.Frontiers in cell and developmental biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hiroki HigashiyamaResearch Center for Integrative Evolutionary Science (RCIES), The Graduate University for Advanced Studies, SOKENDAI, Hayama, Kanagawa, Japan.ORCID 0000-0003-1324-8139
Shunya KurodaInstitute for Frontier Science Initiative, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa, Japan.
Akiyasu IwaseDepartment of Physiological Chemistry and Metabolism, Graduate School of Medicine, The University of Tokyo, Tokyo, Bunkyo-ku, Japan.
Naoki IrieResearch Center for Integrative Evolutionary Science (RCIES), The Graduate University for Advanced Studies, SOKENDAI, Hayama, Kanagawa, Japan.
Hiroki KuriharaDepartment of Physiological Chemistry and Metabolism, Graduate School of Medicine, The University of Tokyo, Tokyo, Bunkyo-ku, Japan.

Funding

Japan Society for the Promotion of Science.
6 · The paper itself

Abstract

The maxillofacial region is one of the most complex areas in the vertebrate body plan. The homology of the upper jaw bones remain controversial, both between mammals and nonmammalian amniotes and among humans and other mammals, leading to various hypotheses on how this region evolved from ancestral amniotes to humans. As a key mammalian model, the mouse (Mus musculus) is vital for unraveling the evolution and development of the maxillofacial region experimentally. However, limited detailed morphological descriptions of murine cranial development hinder the extrapolation of findings to other species, including humans. Here, we describe the development of the murine face, including the nerves, skeletons, and vasculatures from the pharyngula (9.0 days post-coitum [dpc]) to the late fetal period (18.5 dpc) based on three-dimensional reconstructions of histological sections. The present results confirm that the morphology of the pharyngula stages and developmental process of chondrocranium of mice is highly conserved when compared to nonmammalian tetrapods and humans. We also propose that the Os incisivum, the rostralmost bone in the mammalian upper jaw, consists of septomaxillary and palatine components, supporting our previous hypothesis that the ancestral premaxilla was entirely lost in mammals. The present descriptive study of mice strengthen the anatomical correspondence between mouse and human faces and offers a solid framework for comparative craniofacial studies across vertebrates.

Indexed as

MaxillaMaxillofacial DevelopmentAnimalsBiological EvolutionMiceSkullcraniofacialmammalmouseskull

Identifiers

PMID40022452
PMCPMC11871421

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.