ArticleHead & neck2025
Association of Oral Health Determinants With Oral Squamous Cell Carcinoma in Never-Smoking Adults.
Peiran Zhou, Brandon J Yeshoua, Neeraja Konuthula, Cassie J Pan, Rocco M Ferrandino, Sarah E Holte, Zain Rizvi, Emily M Marchiano, Neal D Futran, Brittany R Barber
Abstract read
In one paragraphArticle in Head & neck, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
10 authors.
Peiran ZhouDepartment of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle, Washington, USA.ORCID 0000-0003-4104-5873 Brandon J YeshouaDepartment of Surgery, University of Washington, Seattle, Washington, USA.
Neeraja KonuthulaDepartment of Otolaryngology-Head and Neck Surgery, University of Massachusetts, Worcester, Massachusetts, USA.
Cassie J PanDepartment of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle, Washington, USA.ORCID 0000-0003-2776-4679 Rocco M FerrandinoDepartment of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle, Washington, USA.
Sarah E HolteDepartment of Biostatistics, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
Zain RizviDepartment of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle, Washington, USA.ORCID 0000-0002-2070-2005 Emily M MarchianoDepartment of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle, Washington, USA.
Neal D FutranDepartment of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle, Washington, USA.
Brittany R BarberDepartment of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle, Washington, USA.
Funding
Technology to Empower Changes in Health (TECH) Network Participant Technologies CenterU24OD023176 · OD · SCRIPPS RESEARCH INSTITUTE, THE · PI TOPOL, ERIC JEFFREY · 2016 to 2022
$204.7MPrecision Medicine Initiative Cohort Program BiobankU24OD023121 · OD · MAYO CLINIC ROCHESTER · PI CEKANOVA, MARIA, CICEK, MINE · 2016 to 2024
$185.5MEnhancing All of Us Data Resources for Nutrition Precision Health: the All of Us Data and Research CenterU2COD023196 · OD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GLAZER, DAVID, HARRIS, PAUL A. · 2016 to 2022
$143.7MAdaptive Platform for Personalized EngagementU24OD023163 · OD · VIGNET, INC. · PI JAIN, PRADUMAN · 2017 to 2020
$102.6MUniversity of Arizona-Banner Health All of Us Research Program OT2OD026549 · OD · UNIVERSITY OF ARIZONA · PI MORENO, FRANCISCO A, REIMAN, ERIC MICHAEL · 2018 to 2023
$78.9MCalifornia Precision Medicine Research Program ConsortiumOT2OD026552 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANTON-CULVER, HODA A, OHNO-MACHADO, LUCILA · 2018 to 2023
$73.4MAll of Us PennsylvaniaOT2OD026554 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E, VISWESWARAN, SHYAM · 2018 to 2023
$72.1MNew York City Consortium for Precision MedicineOT2OD026556 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BIER, LOUISE E, GHARAVI, ALI G · 2018 to 2023
$67.3MSouthEast Enrollment Center (SEEC) OT2OD026551 · OD · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CARRASQUILLO, OLVEEN, COLON, VIVIAN · 2018 to 2023
$62.8MSouthern All of Us NetworkOT2OD026548 · OD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI FOUAD, MONA N., KORF, BRUCE R · 2018 to 2023
$60.5MIllinois Precision Medicine Consortium OT2OD026557 · OD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI AHSAN, HABIBUL, ARGOS, MARIA · 2018 to 2023
$60.5MThe New England Precision Medicine Consortium of the All of Us Research ProgramOT2OD026553 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI CLARK, CHERYL RENEE, KARLSON, ELIZABETH W · 2018 to 2023
$58.8MNIDCD NIH HHS R25 DC021791NIDCD NIH HHS T32 DC000018NIH HHS OT2 OD023205NIH HHS OT2 OD023206NIH HHS OT2 OD025276NIH HHS OT2 OD025277NIH HHS OT2 OD025315NIH HHS OT2 OD025337NIH HHS OT2 OD026548NIH HHS OT2 OD026549NIH HHS OT2 OD026550NIH HHS OT2 OD026551NIH HHS OT2 OD026552NIH HHS OT2 OD026553NIH HHS OT2 OD026554NIH HHS OT2 OD026555NIH HHS OT2 OD026556NIH HHS OT2 OD026557NIH HHS U24 OD023121NIH HHS U24 OD023163NIH HHS U24 OD023176NIH HHS U2C OD023196RFPU-NW research award
6 · The paper itselfAbstract
backgroundThe incidence of oral cavity squamous cell carcinoma (OCSCC) is increasing among non-smokers. This study investigates the association between local and systemic oral health determinants and OCSCC in never-smoking adults.
methodsA case-control study using the National Institutes of Health All of Us database was conducted. Lifetime exposures to periodontal disease, acquired absence of teeth, hyperlipidemia, hyperglycemia, HIV, oral-related autoimmune diseases, depression, and eating disorders were analyzed. Multivariate logistic regression estimated odds ratios (ORs) and 95% confidence intervals to identify independent OCSCC risk factors.
resultsSeveral risk factors were independently associated with OCSCC: periodontal disease (OR 4.99), hyperlipidemia (OR 1.53), HIV infection (OR 2.96), oral-related autoimmune diseases (OR 2.40), depression (OR 1.51), and eating disorders (OR 8.46). Acquired absence of teeth and hyperglycemia did not show statistical significance.
conclusionsThis study highlights the complex pathophysiology of OCSCC in never-smoking adults and underscores the need for comprehensive risk assessment and prevention strategies.
Indexed as
Carcinoma, Squamous CellMouth NeoplasmsOral HealthAdultAgedCase-Control StudiesDatabases, FactualFemaleHumansIncidenceLogistic ModelsMaleMiddle AgedNon-SmokersPeriodontal DiseasesRisk Assessmentnonsmokingoral cancerrisk factors
Identifiers
PMID40022306
PMCPMC12148706
What OpenQuestion holds
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