Evidence map›Paper›PMID 40022289›Full record

ReviewBrain and behavior2025

Cerebral Venous Thrombosis and Nitrous Oxide Intoxication: Report of Two Cases and Review of the Literature.

Diana Doukhi, Virginie Siguret, Dominique Vodovar, Maxime Delrue, Peggy Reiner, Agnes Aghetti, Stéphanie Guey, Mikael Mazighi, Isabelle Crassard

Abstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Diana DoukhiNeurology Department, Hôpital Lariboisière, APHP, Paris, France.ORCID https://orcid.org/0009-0008-9359-0471
Virginie SiguretUniversité Paris Cité, Paris, France.ORCID https://orcid.org/0000-0002-6509-8964
Dominique VodovarMédecine Intensive Réanimation, Hôpital Charles Nicolle, Rouen, France.ORCID https://orcid.org/0000-0002-6320-2887
Maxime DelrueHematology Laboratory Department, Hôpital Lariboisière, APHP, Paris, France.
Peggy ReinerNeurology Department, Hôpital Lariboisière, APHP, Paris, France.
Agnes AghettiNeurology Department, Hôpital Lariboisière, APHP, Paris, France.
Stéphanie GueyNeurology Department, Hôpital Lariboisière, APHP, Paris, France.
Mikael MazighiNeurology Department, Hôpital Lariboisière, APHP, Paris, France.
Isabelle CrassardNeurology Department, Hôpital Lariboisière, APHP, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCerebral venous thrombosis (CVT) has various risk factors, including contraception, pregnancy, neoplasia, and thrombophilia. Nitrous oxide (N₂O), historically used as an anesthetic and more recently as a recreational drug, has been associated with neurological complications such as myeloneuropathy and thromboembolic events. Here, we report two cases of CVT associated with N₂O use and provide a review of the literature on this association.

methodsWe describe two local cases of CVT associated with N

resultsAmong the 12 patients, seven had co-existing CVT risk factors. Most patients reported chronic N

conclusionsThese cases highlight an emerging association between CVT and N₂O use. Prompt recognition of this link is critical to recommend cessation of N₂O use, alongside anticoagulation therapy and consideration of vitamin supplementation to prevent complications and recurrence.

Indexed as

Anesthetics, InhalationIntracranial ThrombosisNitrous OxideSubstance-Related DisordersVenous ThrombosisAnticoagulantsHumansAnesthetics, InhalationAnticoagulantsNitrous Oxidecerebral venous thrombosisdrughomocysteinenitrous oxidevitamin B12

Identifiers

PMID40022289
PMCPMC11870820

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.