ArticleBrain and behavior2025
Impact of Native Probiotics on Autophagy and Oxidative Stress in Nickel-Exposed Mice: Insights Into the Gut-Brain Axis.
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe gut-brain axis plays a crucial role in mitigating the adverse effects of environmental agents such as nickel exposure. Nickel, recognized as a heavy metal, poses significant concerns for public health because of its impact on neurological disorders and oxidative stress; consequently, it is prioritized for evaluations of its effects on biological pathways. This study investigates the potential of native probiotic strains to modulate inflammatory and autophagy signaling pathways, which are vital for combating oxidative stress.
methodsTwenty male NMRI mice were divided into 4 groups randomly and were gavaged with NiCl
resultsOur findings demonstrated that treatment with this cocktail of native probiotic Lactobacillus spp. and Bifidobacterium spp. significantly increased the expression of autophagy genes compared to the control group exposed to NiCl
conclusionThe beneficial effects of our native probiotic strains were confirmed through enhanced expression of autophagy genes and reduced neuroinflammation, suggesting their potential as therapeutic agents in mitigating the adverse impacts of nickel exposure on brain health via modulation of the gut-brain axis.
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