Evidence map›Paper›PMID 40022191›Full record

ArticleRespiratory research2025

Vascular remodeling and TSLP/angiogenin overexpression in severe mixed asthma.

Francesca Bertolini, Vitina M A Carriero, Elisa Arrigo, Giuseppe Guida, Stefano Levra, Stefano Pizzimenti, Mirella Profita, Isabella Gnemmi, Antonino Di Stefano, Fabio L M Ricciardolo

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In one paragraph

Article in Respiratory research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Vascular remodeling in asthma: from mechanisms to precision medicine.Current opinion in allergy and clinical immunology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Francesca Bertolini *Department of Clinical and Biological Sciences, University of Turin, Turin, TO, Italy.
Vitina M A Carriero *Department of Clinical and Biological Sciences, University of Turin, Turin, TO, Italy.
Elisa ArrigoDepartment of Clinical and Biological Sciences, University of Turin, Turin, TO, Italy.
Giuseppe GuidaDepartment of Clinical and Biological Sciences, University of Turin, Turin, TO, Italy.
Stefano LevraDepartment of Clinical and Biological Sciences, University of Turin, Turin, TO, Italy.
Stefano PizzimentiRare Lung Disease and Respiratory Pathophysiology Unit, Severe Asthma, San Luigi Gonzaga University Hospital, Orbassano, Turin, TO, Italy.
Mirella ProfitaInstitute of Translational Pharmacology, section of Palermo, National Research Council (IFT-CNR), Palermo, 90146, PA, Italy.
Isabella GnemmiDivisione di Pneumologia and Laboratorio di Citoimmunopatologia dell'Apparato Cardio Respiratorio, IRCCS, Respiratory Rehabilitation Unit of Gattico-Veruno, Istituti Clinici Scientifici Maugeri, Novara, 28013, NO, Italy.
Antonino Di StefanoDivisione di Pneumologia and Laboratorio di Citoimmunopatologia dell'Apparato Cardio Respiratorio, IRCCS, Respiratory Rehabilitation Unit of Gattico-Veruno, Istituti Clinici Scientifici Maugeri, Novara, 28013, NO, Italy.
Fabio L M RicciardoloDepartment of Clinical and Biological Sciences, University of Turin, Turin, TO, Italy. fabioluigimassimo.ricciardolo@unito.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAsthma with neutrophilic/mixed inflammation is a difficult-to-control clinical phenotype. Currently, vascular and matrix airway remodeling in asthma with neutrophilic/mixed inflammation is not well known. We aimed to evaluate the differences in vascular/smooth muscle/matrix related asthma remodeling in eosinophilic (EOS) and mixed/neutrophilic (MIXED) bronchial phenotypes in relation to asthma severity and exacerbation frequency.

methodsIn this cross-sectional study, α-SMA

resultsThe number of CD31

conclusionThe severe or frequent exacerbator asthmatics with bronchial mixed inflammatory profile are characterized by increased number of vessels and overexpression of TSLP and angiogenin, suggesting a pathogenetic link between mixed eosinophilic and neutrophilic inflammation and vascular remodeling.

Indexed as

AsthmaCytokinesRibonuclease, PancreaticSeverity of Illness IndexVascular RemodelingAdultBiomarkersCross-Sectional StudiesFemaleHumansMaleMiddle AgedThymic Stromal LymphopoietinangiogeninBiomarkersCytokinesRibonuclease, PancreaticThymic Stromal LymphopoietinTSLP protein, humanAsthma exacerbationMatrix-related remodelingMixed/neutrophilic asthmaSevere asthmaVascular remodeling

Identifiers

PMID40022191
PMCPMC11871842

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.