ArticleCardiovascular diabetology2025
Association between triglyceride glucose index and biological aging in U.S. adults: National Health and Nutrition Examination Survey.
Article in Cardiovascular diabetology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- The inverse association between skeletal muscle mass to visceral fat ratio (SVR) and sleep disturbance: the mediating role of inflammation and aging acceleration.BMC psychiatry · 2026Article
- Association Between Estimated Glucose Disposal Rate and Biological Aging Among U.S. Adults: A Cross-Sectional Study.Health science reports · 2026Article
- The association of time-restricted eating and indices of organ-specific aging in relation to metabolic health and obesity.NPJ science of food · 2026Article
- Triglyceride glucose index-a body shape index (TyG-ABSI) outperforms traditional obesity indices in predicting all-cause and cardiovascular mortality in metabolic-dysfunction associated steatotic liver disease: the mediating role of biological aging.Cardiovascular diabetology · 2026Article
- The mediating role of insulin resistance in depression driving phenotypic age acceleration.Annals of general psychiatry · 2026Article
- TyG Index and Obesity-Related Measures in Relation to All-Cause Mortality Among HSV-Positive Adults.International journal of endocrinology · 2026Article
- Associations between novel triglyceride glucose and adiposity-related indices and risk of metabolic dysfunction-associated steatotic liver disease: the mediating role of biological aging and evidence from the UK Biobank.Frontiers in endocrinology · 2026Article
- Triglyceride glucose related indices predict incident breast cancer risk in a population based cohort study.Discover oncology · 2025Article
- Association of estimated glucose disposition rate with aging acceleration and mortality risk in individuals with cardiovascular-kidney-metabolic syndrome: evidence from two large national population-based studies.Cardiovascular diabetology · 2025Article
- Sex-stratified and ascorbic acid intake-modified associations between body roundness index and biological aging: a NHANES-based study on interactions and mediation.Lipids in health and disease · 2025Article
- Associations of Estimated Glucose Disposal Rate With Stroke Risk and Poststroke Adverse Outcomes: A Prospective Cohort Study.CNS neuroscience & therapeutics · 2025Article
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- The role of triglyceride-glucose index in the progression of cardiovascular-kidney-metabolic syndrome: findings from the China health and retirement longitudinal study.Frontiers in cardiovascular medicine · 2025Article
- Sex-Specific Cardiometabolic Phenotypes of Metabolic Syndrome Identified by Latent Class Analysis in Indian Adults.International journal of applied & basic medical researchArticle
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2 authors.
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Abstract
backgroundInsulin resistance (IR) has been reported to be associated with aging; however, few studies have investigated the relationship between IR and biological age (BA). The Triglyceride-glucose (TyG) index is a recognized marker of IR. Currently, there is insufficient evidence regarding the relationship between the TyG index and biological aging. This study aims to provide deeper insights into the connections between the TyG index and biological aging.
methodsWe conducted a cross-sectional study using data from the National Health and Nutrition Examination Survey (NHANES), including 12,074 adults (aged 20 and older) from the 2001-2010 and 2015-2018 cycles. Comprehensive TyG and BA data were extracted for analysis. To explore the relationship between the TyG index and BA, linear regressions were employed, while logistic regression models were used to examine the association between the TyG index and accelerated aging. Additionally, trend tests, subgroup analyses, and smoothed fitted curves were conducted to assess the robustness of the findings.
resultsWe included 12,074 participants with a mean age of 46.91 years (SD, 16.64); of these, 50.25% were female and 49.75% were male. Each 1-unit increase in the TyG index was associated with a 1.64-year rise in Klemera-Doubal method (KDM) biological age and a 117% higher risk of accelerated aging. Similarly, each 1-unit increase in the TyG index corresponded to a 0.40-year increase in phenotypic age, resulting in a 15% higher risk of accelerated aging. The analysis also revealed nonlinear positive relationships between the TyG index and biological aging, particularly for KDM biological age (P for non-linearity < 0.001) and phenotypic age (P for non-linearity = 0.005), with a turning point at 8.66. Across all subgroups, the TyG index consistently showed a positive correlation with biological aging, even in the presence of significant interactions.
conclusionsThere is a significant positive association between the TyG index and biological aging. Higher TyG levels are linked to increased biological age and a greater risk of accelerated aging.
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