ArticleRespiratory research2025
The role of wheezing subtypes in the development of early childhood asthma.
Article in Respiratory research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Parental asthma and childhood asthma phenotypes: maternal associations with persistent asthma.BMJ open respiratory research · 2026Article
- Bridging Respiratory Exposures, Asthma, and Environmental Health in Corpus Christi (BREATHE-CC): a prospective cohort study protocol.BMC public health · 2026Article
- An expert opinion on the management of pediatric patients with wheezing and mild asthma: translating 2025 GINA strategy report into clinical practice in Italy.Italian journal of pediatrics · 2026Review
- Short-term efficacy of nebulized budesonide for allergic airway inflammation in young children and dynamic changes in fractional exhaled nitric oxide (FeNO): a retrospective cohort study.American journal of translational research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundEarly childhood wheezing is associated with asthma risk at later ages, emphasizing the need for understanding wheezing patterns and their implications for asthma development.
methodsChildren in the F2-generation (n = 603) of the Isle of Wight Birth Cohort (IOWBC) were followed-up at 3, 6, 12, 24, 36, and 72 months. Prevalence of wheeze and wheeze type (general, infectious, and non-infectious) were recorded. Group-based trajectory models covering ages 3 to 36 months were used to identify early childhood wheezing trajectories for each type of wheeze. These trajectories were examined for their association with asthma status and lung function at 6 years and later.
resultsDistinct trajectories for general ("Persistent", "Transient", "Progressive", and "Infrequent/Never"), infectious ("Persistent", "Transient", and "Infrequent/Never"), and non-infectious ("Progressive", "Early Occurrence", and "Infrequent/Never") wheezing were identified. Compared to the "Infrequent/Never" trajectories, four trajectories were associated with an increased risk of asthma, namely "Progressive" non-infectious, "Early Occurrence" non-infectious, "Persistent" infectious, and "Persistent" general wheeze trajectories.
conclusionsThe identification of wheeze trajectories across different etiologies as significant risk factors for asthma may aid in understanding the complex, multifactorial nature of asthma onset. The findings suggest that early identification of specific wheeze patterns, not just occurrence of wheezing, can inform clinical interventions and potentially mitigate the risk of developing asthma.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.