Evidence map›Paper›PMID 40022089›Full record

Trial reportBMC oral health2025

Efficacy of different forms of concentrated growth factors combined with deproteinized bovine bone minerals in guided bone regeneration: a randomized clinical trial.

Lingshan Zhu, Xichen Du, Gang Fu, Li Wang, Hong Huang, Xiaohong Wu, Binting Xu

Abstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lingshan Zhu *College of Stomatology, Chongqing Medical University, 426# Songshi North Road, Chongqing, 401147, China.
Xichen Du *Mianyang Hospital of T.C.M, Mianyang, China.
Gang FuCollege of Stomatology, Chongqing Medical University, 426# Songshi North Road, Chongqing, 401147, China.
Li WangCollege of Stomatology, Chongqing Medical University, 426# Songshi North Road, Chongqing, 401147, China.
Hong HuangCollege of Stomatology, Chongqing Medical University, 426# Songshi North Road, Chongqing, 401147, China.
Xiaohong WuCollege of Stomatology, Chongqing Medical University, 426# Songshi North Road, Chongqing, 401147, China.
Binting XuCollege of Stomatology, Chongqing Medical University, 426# Songshi North Road, Chongqing, 401147, China. bintingxu@hospital.cqmu.edu.cn.

Funding

2020 Clinical Research Project of Chongqing Medical University Affiliated Stomatological Hospital lcky2020022020 Clinical Research Project of Chongqing Medical University Affiliated Stomatological Hospital lcky2020062023 New Technology and New Project of Chongqing Medical University Affiliated Stomatological Hospital QYYL2023X0152024 Science Bureau Joint Health Commission Medical Research Project of Chongqing 2024MSXM067
6 · The paper itself

Abstract

objectivesTo explore the bone regeneration effect of different forms of concentrated growth factor (CGF) when combined with deproteinized bovine bone mineral (DBBM) for simultaneous implant-guided bone regeneration (GBR) and its impact on postoperative adverse reactions.

methodsFifty-seven patients who underwent simultaneous implant GBR were selected for the study and divided into three groups. The study involved three groups: the gel phase concentrated growth factor (GPCGF) group, which used GPCGF-DBBM mixture; the liquid phase concentrated growth factor (LPCGF) group, which used LPCGF-DBBM mixture; and the control group, which used DBBM alone. The thickness of the buccal lateral bones was measured using cone beam computed tomography (CBCT), and patients were asked to complete questionnaires to assess primary adverse reactions during the first week after surgery. The data were analyzed using one-way ANOVA, Tukey test, and Kruskal-Wallis test.

resultsThe buccal lateral bone thickness in the GPCGF, LPCGF, and control groups decreased significantly at 6 months post-surgery compared to immediately after surgery. The change of bone thickness in the GPCGF group was lower than that in the control group (p < 0.01), and that in the LPCGF group did not differ from that in the control group (p > 0.05). During the postoperative week, statistically significant differences could be observed in bleeding, mouth opening, chewing, sleeping, speaking, daily routine, and pain (p < 0.05).

conclusionsCompared to the DBBM applied alone, the GPCGF-DBBM mixture has more positive implications for reducing bone resorption, promoting bone reconstruction and relieving certain postoperative adverse effects in dental implants with simultaneous GBR. The GPCGF-DBBM mixture was superior to the LPCGF-DBBM mixture in alleviating adverse effects in terms of bleeding and speaking after GBR. CLINICAL TRIALS REGISTRATION NUMBER: The Chinese Clinical Trial Registry, NO. ChiCTR2300070107 (03/04/2023).

Indexed as

Bone RegenerationBone SubstitutesGuided Tissue Regeneration, PeriodontalIntercellular Signaling Peptides and ProteinsMineralsAdultAnimalsCattleCone-Beam Computed TomographyDental Implantation, EndosseousFemaleHumansMaleMiddle AgedTreatment OutcomeBio-OssBone SubstitutesIntercellular Signaling Peptides and ProteinsMineralsConcentrated growth factorsDental implantsGuided bone regenerationPostoperative adverse reaction

Identifiers

PMID40022089
PMCPMC11869682

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.