SynthesisBMC pregnancy and childbirth2025
The association between interpregnancy intervals and preterm birth: a systematic review and meta-analysis.
Synthesis in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- FIGO good practice recommendations on preconception care: A strategy to prevent preterm birth.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025Guideline
- Impact of Short and Long Interpregnancy Intervals on Neonatal Outcomes: A Multiclassification Cohort Analysis.Healthcare (Basel, Switzerland) · 2026Article
- Interpregnancy Interval and the Degree of Cystocele Across Two Vaginal Deliveries: A Retrospective Self-Controlled Cohort Study Using Transperineal Ultrasound.International journal of women's health · 2026Article
- Temporal trend and influencing factors of high-risk pregnancy in China: a nationwide longitudinal analysis.Frontiers in public health · 2026Article
- Interpregnancy Interval as a Determinant of Outcome in Women with Prophylactic Cerclage Following Preterm Birth or Late Miscarriage.Geburtshilfe und Frauenheilkunde · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundResearch has shown a relationship between interpregnancy intervals (IPIs) and preterm birth, but a comprehensive understanding remains elusive. The aim of this systematic review and meta-analysis was to examine the effect of different IPIs on the risk of preterm birth
methodsSystematic searches were conducted in PubMed, Cochrane, Web of Science, and Embase up to June 2, 2023. Studies included in the review provided data on IPIs and preterm birth outcomes, assessed via the NOS quality scale. A Bayesian network meta-analysis was performed to evaluate the association between IPIs and preterm birth.
resultsFrom 34 studies and 8,646,679 individuals, the optimal IPIs were found to be 24-29 months, showing significantly lower risks of preterm birth at less than 32 weeks of gestation [OR=0.55 (95%CI: 0.50 - 0.62)]and at less than 37 weeks of gestation[OR=0.61 (95%CI: 0.59 - 0.63)]compared to IPIs less than 5 months.
conclusionsIPIs of 24-29 months significantly reduce the risk of preterm birth, suggesting a potential target range for family planning and clinical recommendations.
trial registrationNot applicable.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.