Evidence map›Paper›PMID 40021975›Full record

Trial reportBMC psychiatry2025

Group integrated exercise versus recovery class for veterans with posttraumatic stress disorder: a randomized clinical trial.

Thomas C Neylan, Laura A Muratore, Chanda L Williams, Martha Schmitz, Courtney V Valdez, Shira Maguen, Aoife O'Donovan, D Parker Kelley, Thomas J Metzler, Beth E Cohen and 7 more

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02856412 (Improving Mind/Body Health and Functioning With Integrative Exercise), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02856412 nacompletednot on this map

Improving Mind/Body Health and Functioning With Integrative Exercise

TypeinterventionalSponsorVA Office of Research and DevelopmentRan2017 to 2023Enrolled84ConditionsStress Disorders, Post-TraumaticArmsVeterans Group Exercise (VGX), Illness Management and Recovery
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Thomas C NeylanSan Francisco Veterans Affairs Medical Center, San Francisco, CA, USA. Thomas.Neylan@ucsf.edu.
Laura A MuratoreSan Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.
Chanda L WilliamsSan Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.
Martha SchmitzSan Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.
Courtney V ValdezSan Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.
Shira MaguenSan Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.
Aoife O'DonovanSan Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.
D Parker KelleySan Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.
Thomas J MetzlerSan Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.
Beth E CohenSan Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.
Anna C WestSan Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.
Jordan D V PhanSan Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.
Victor AntonettiSan Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.
Olga MayzelSan Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.
Jennifer A HlavinSan Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.
Margaret A ChesneySan Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.
Wolf E MehlingSan Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.

Funding

Clinical Features and Neuropathological Basis of Sleep Wake Behavior in Alzheimer's and PSPR01AG060477 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Lea Tenenholz Grinberg, Thomas C Neylan · 2019 to 2026
$8.2M
NIA NIH HHS R01 AG060477RRD VA I01 RX001939Veterans Affairs 5I01RX001939
6 · The paper itself

Abstract

There are no reported randomized trials testing exercise versus an active comparator for Posttraumatic Stress Disorder (PTSD). This randomized clinical trial assessed the effectiveness of group exercise versus psychoeducation to improve quality of life and reduces symptomatic severity in Veterans with PTSD. Veterans who met criteria for current PTSD (DSM-5) and/or endorsed moderate levels of PTSD symptoms (CAPS 5 score ≥ 23) were randomly assigned to treatment. Integrative Exercise (IE) combines fitness exercises (aerobics, resistance training, stretching) with mindful body/breath awareness versus Recovery Class (REC) psychoeducation control condition. A total of 84 participants were enrolled of which 41 participants were randomized to IE and 43 participants to REC. There were no significant pre-post differences in change in the WHOQOL Psychological Domain in either group. There was a modest reduction in the total CAPS-5 score in both groups (IE: -8.2 (9.9), p < .001: REC: -7.8 (2.0), p < .001) but no differences across the two conditions. In the IE subsample that was remote, there was a greater improvement in PTSD symptom severity (F[1, 50] = 4.62, p = .036) and in in the WHOQOL Psychological Domain (F(1, 47) = 6.46, p = .014) in those who attended more sessions. Trial registration ClinicalTrials.gov Identifier: NCT02856412 (registration date: February 27, 2017).

Indexed as

Exercise TherapyStress Disorders, Post-TraumaticVeteransAdultFemaleHumansMaleMiddle AgedQuality of LifeResistance TrainingTreatment OutcomeExercisePsychoeducationPTSDRandomized controlled trialVeteran

Identifiers

PMID40021975
PMCPMC11871828

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.