Evidence map›Paper›PMID 40021935›Full record

ArticleNature metabolism2025

Discovery of metabolites prevails amid in-source fragmentation.

Yasin El Abiead, Adriano Rutz, Simone Zuffa, Bashar Amer, Shipei Xing, Corinna Brungs, Robin Schmid, Mario S P Correia, Andres Mauricio Caraballo-Rodriguez, Amir Zarrinpar and 16 more

Abstract readLetter
In one paragraph

Article in Nature metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Review
  2. Chronic changes in acute zonal occult outer retinopathy mimicking non-progressive retinitis pigmentosa: clinical and laboratory characteristics.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Article
  3. Article
  4. Assessing the metabolomics "dark matter" by a detectable khipu model.Metabolomics : Official journal of the Metabolomic Society · 2026
    Article
  5. Review
  6. Mapping the mammalian dark metabolome bybioRxiv : the preprint server for biology · 2026
    Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Constructing a consensus serum metabolome.bioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Yasin El Abiead *Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA.
Adriano Rutz *Institute for Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0003-0443-9902
Simone ZuffaSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-7237-3402
Bashar AmerThermo Fisher Scientific, San Jose, CA, USA.
Shipei XingSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-6227-6959
Corinna BrungsInstitute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic.ORCID http://orcid.org/0000-0002-2571-5235
Robin SchmidInstitute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic.
Mario S P CorreiaInstitute for Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.
Andres Mauricio Caraballo-RodriguezSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA.
Amir ZarrinparDivision of Gastroenterology, University of California, San Diego, La Jolla, CA, USA.
Helena Mannochio-RussoSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA.
Michael WittingMetabolomics and Proteomics Core, Helmholtz Zentrum München, Neuherberg, Germany.ORCID http://orcid.org/0000-0002-1462-4426
Ipsita MohantySkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA.
Tomáš PluskalInstitute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic.ORCID http://orcid.org/0000-0002-6940-3006
Wout BittremieuxDepartment of Computer Science, University of Antwerp, Antwerp, Belgium.ORCID http://orcid.org/0000-0002-3105-1359
Rob KnightShu Chien-Gene Lay Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
Andrew D PattersonDepartment of Biochemistry and Molecular Biology and Department of Veterinary and Biomedical Sciences, the Pennsylvania State University, University Park, PA, USA.
Justin J J van der HooftBioinformatics Group, Wageningen University, Wageningen, the Netherlands.ORCID http://orcid.org/0000-0002-9340-5511
Sebastian BöckerInstitute of Computer Science, Friedrich Schiller University Jena, Jena, Germany.ORCID http://orcid.org/0000-0002-9304-8091
Warwick B DunnDepartment of Biochemistry, Cell and Systems Biology, Centre for Metabolomics Research, Institute of Systems, Molecular, and Integrative Biology, University of Liverpool, Liverpool, UK.ORCID http://orcid.org/0000-0001-6924-0027
Roger G LiningtonDepartment of Chemistry, Simon Fraser University, Burnaby, British Columbia, Canada.ORCID http://orcid.org/0000-0003-1818-4971
David S WishartDepartment of Biological Science, University of Alberta, Edmonton, Alberta, Canada.ORCID http://orcid.org/0000-0002-3207-2434
Jean-Luc WolfenderInstitute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland.ORCID http://orcid.org/0000-0002-0125-952X
Oliver FiehnWest Coast Metabolomics Center, University of California, Davis, Davis, CA, USA.ORCID http://orcid.org/0000-0002-6261-8928
Nicola ZamboniInstitute for Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0003-1271-1021
Pieter C DorresteinSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA. pdorrestein@ucsd.edu.ORCID http://orcid.org/0000-0002-3003-1030

Funding

Development of Engineered Native Bacteria as a Tool for Functional Manipulation of the Gut MicrobiomeR01AI163483 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEFF M HASTY, Amir Zarrinpar · 2023 to 2026
$3.1M
Design and characterization of bacterial population dynamics in solid tumor modelsR01EB030134 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HASTY, JEFF M, TSIMRING, LEV S · 2021 to 2024
$2.5M
BLRD VA I01 BX005707NIAID NIH HHS R01 AI163483NIBIB NIH HHS R01 EB030134U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) NIH U24DK133658
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID40021935
PMCPMC13111153

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.