Evidence map›Paper›PMID 40021925›Full record

Reviewnpj antimicrobials and resistance2025

R-pyocins as targeted antimicrobials against Pseudomonas aeruginosa.

Madeline Mei, Isaac Estrada, Stephen P Diggle, Joanna B Goldberg

Abstract readReview
In one paragraph

Review in npj antimicrobials and resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Article
  3. R pyocin sensitivity ofJournal of medical microbiology · 2026
    Article
  4. Article
  5. Article
  6. Lipopolysaccharide-targeting treatments for multidrug-resistantExpert opinion on therapeutic targets · 2026
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Madeline MeiDivision of Pulmonary, Asthma, Cystic Fibrosis and Sleep, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
Isaac EstradaCenter for Microbial Dynamics and Infection, School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.
Stephen P DiggleCenter for Microbial Dynamics and Infection, School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.
Joanna B GoldbergDivision of Pulmonary, Asthma, Cystic Fibrosis and Sleep, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA. joanna.goldberg@emory.edu.

Funding

Training a New Generation of VaccinologistsT32AI074492 · NIAID · EMORY UNIVERSITY · PI Rama Rao Amara, Benjamin A Lopman · 2009 to 2026
$6.4M
Understanding in vivo antibiotic resistance in diverse Pseudomonas aeruginosa populationsR01AI153116 · NIAID · GEORGIA INSTITUTE OF TECHNOLOGY · PI DIGGLE, STEPHEN PAUL · 2021 to 2025
$2.3M
Pyocins as antibacterials to treat Pseudomonas aeruginosa infectionsR21AI178702 · NIAID · EMORY UNIVERSITY · PI GOLDBERG, JOANNA B · 2023 to 2024
$458k
Cystic Fibrosis Foundation GOLDBE23G0; DIGGLE18I0; DIGGLE20G0NIAID NIH HHS R01 AI153116NIAID NIH HHS R21 AI178702NIAID NIH HHS T32 AI074492NIH HHS R21 AI17802; R01AI153116; T32AI074492
6 · The paper itself

Abstract

R-pyocins, bacteriocin-like proteins produced by Pseudomonas aeruginosa, present a promising alternative to phage therapy and/or adjunct to currently used antimicrobials in treating bacterial infections due to their targeted specificity, lack of replication, and stability. This review explores the structural, mechanistic, and therapeutic aspects of R-pyocins, including their potential for chronic infection management, and discusses recent advances in delivery methods, paving the way for novel antimicrobial applications in clinical settings.

Identifiers

PMID40021925
PMCPMC11871291

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.