SynthesisNature communications2025
GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets.
Abstract readMeta-Analysis
In one paragraph
Synthesis in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
63 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Integration of GWAS and single-cell analysis for psoriasis identifies disease-associated cell subtypes and therapeutic targets.Nature communications · 2026Pooled it
- IL31 identified as a key genetic risk factor for prurigo nodularis.The Journal of allergy and clinical immunology · 2025Pooled it
- Article
- Polygenic Risk Scores Show Distinct Genetic Architectures of IBD-Associated Comorbidities.Digestive diseases and sciences · 2026Article
- Article
- Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy.Phytotherapy research : PTR · 2026Review
- Immunogenetics in psoriasis: towards personalised diagnosis and treatment strategies.Genes and immunity · 2026Review
- Real-World Long-Term Effectiveness and Safety of Secukinumab in Psoriasis: Up to 7 Years of Evidence from the Italian Landscape Psoriasis (IL PSO) Multicenter Retrospective Study.Dermatology and therapy · 2026Article
- Divergent Paths: A Comprehensive Review of Mechanisms and Clinical Implications in Atopic Dermatitis and Psoriasis.Allergy · 2026Review
- Development of IgA nephropathy following risankizumab therapy for psoriatic arthritis: a case report.CEN case reports · 2026Article
- Integrated multi-omics strategies for identifying novel therapies in psoriasis.Bioinformatics (Oxford, England) · 2026Article
- Application of GBD 2021 and multiple omics to reveal the association and potential mechanism between glycated hemoglobin and intervertebral disc degeneration.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Associations of plasma proteomic and polygenic profiling with incident psoriasis risk: a prospective cohort study.Journal of global health · 2026Article
- Genome-Wide Association Study of Psoriasis, Psoriatic Arthritis, Anti-TNF-α Response, and Polygenic Risk Score in a Russian Cohort.International journal of molecular sciences · 2026Article
- Multi‑omics and their integration in psoriasis research (Review).Molecular medicine reports · 2026Review
- Transcobalamin 1 is a keratinocyte-derived autoantigen driving psoriasis through T helper 17 cell activation.Science advances · 2026Article
- TYMP upregulation mediated by the hyperactivated IL-17/NF-κB1 axis promotes psoriasis through enhancing aberrant keratinization and neutrophil-mediated inflammation.Biology direct · 2026Article
- Genetic Association Study ofLife (Basel, Switzerland) · 2026Article
- Review
- Hidden immune memory niches in inflammatory skin diseases.bioRxiv : the preprint server for biology · 2026Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
- Update of
Authors and funding
87 authors.
Nick DandDepartment of Medical & Molecular Genetics, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.ORCID http://orcid.org/0000-0002-1805-6278
Philip E StuartDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.
John BowesCentre for Genetics and Genomics Versus Arthritis, The University of Manchester, Manchester, UK.ORCID http://orcid.org/0000-0003-4659-031X
David EllinghausInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.ORCID http://orcid.org/0000-0002-4332-6110
Joanne NitithamDeparment of Dermatology, University of California San Francisco, San Francisco, CA, USA.
Jake R SaklatvalaDepartment of Medical & Molecular Genetics, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.ORCID http://orcid.org/0000-0003-0836-4928
Maris Teder-LavingInstitute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0002-5872-1850
Laurent F ThomasDepartment of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.ORCID http://orcid.org/0000-0003-0548-2486
Tanel TraksDepartment of Dermatology and Venereology, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia.
Steffen UebeInstitute of Human Genetics, Universitätsklinikum Erlangen, FAU Erlangen-Nürnberg, Erlangen, Germany.
Gunter AssmannRUB University Hospital JWK Minden, Department of Rheumatology, Minden, Germany.
David BaudrySt John's Institute of Dermatology, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.
Frank BehrensDivision of Translational Rheumatology, Immunology - Inflammation Medicine, University Hospital, Goethe University, Frankfurt am Main, Germany.
Allison C BilliDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-7115-9113
Matthew A BrownDepartment of Medical & Molecular Genetics, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.ORCID http://orcid.org/0000-0003-0538-8211
Harald BurkhardtFraunhofer Institute for Translational Medicine and Pharmacology ITMP, Frankfurt am Main, Germany.ORCID http://orcid.org/0000-0002-6261-3131
Francesca CaponDepartment of Medical & Molecular Genetics, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.ORCID http://orcid.org/0000-0003-2432-5793
Raymond ChungInstitute of Psychiatry, Psychology and Neuroscience, King's College London, Denmark Hill, Camberwell, London, UK.
Charles J CurtisInstitute of Psychiatry, Psychology and Neuroscience, King's College London, Denmark Hill, Camberwell, London, UK.
Michael DuckworthSt John's Institute of Dermatology, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.ORCID http://orcid.org/0000-0003-0295-9621
Eva EllinghausInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.ORCID http://orcid.org/0000-0003-2914-3382
Oliver FitzGeraldUCD School of Medicine and Medical Sciences and Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland.ORCID http://orcid.org/0000-0002-6607-6070
Sascha GerdesDepartment of Dermatology, Venereology and Allergy, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Christopher E M GriffithsSt John's Institute of Dermatology, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.
Susanne GulliverNewlab Clinical Research Inc, St. John's, NL, Canada.
Philip S HelliwellLeeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK.
Pauline HoCentre for Genetics and Genomics Versus Arthritis, The University of Manchester, Manchester, UK.
Per HoffmannInstitute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0002-6573-983X
Oddgeir L HolmenHUNT Research Centre, Department of Public Health and Nursing, NTNU - Norwegian University of Science and Technology, Levanger, Norway.
Zhi-Ming HuangDeparment of Dermatology, University of California San Francisco, San Francisco, CA, USA.
Kristian HveemK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.
Deepak JadonDepartment of Medicine, University of Cambridge, Cambridge, UK.
Michaela KöhmDivision of Translational Rheumatology, Immunology - Inflammation Medicine, University Hospital, Goethe University, Frankfurt am Main, Germany.
Cornelia KrausInstitute of Human Genetics, Universitätsklinikum Erlangen, FAU Erlangen-Nürnberg, Erlangen, Germany.
Céline LamacchiaDivision of Rheumatology, Geneva University Hospital, Geneva, Switzerland.
Sang Hyuck LeeInstitute of Psychiatry, Psychology and Neuroscience, King's College London, Denmark Hill, Camberwell, London, UK.
Feiyang MaDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.
Satveer K MahilSt John's Institute of Dermatology, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.ORCID http://orcid.org/0000-0003-4692-3794
Neil McHughDepartment of Life Sciences, University of Bath, Bath, UK.
Ross McManusDepartment of Clinical Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.ORCID http://orcid.org/0000-0002-0529-9617
Ellen H ModalsliDepartment of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.
Michael J NissenDivision of Rheumatology, Geneva University Hospital, Geneva, Switzerland.
Markus NöthenInstitute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0002-8770-2464
Vinzenz OjiDepartment of Dermatology, University of Münster, Münster, Germany.
Jorge R OksenbergWeill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-3613-9544
Matthew T PatrickDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-6174-9002
Bethany E Perez WhiteDepartment of Dermatology, Northwestern University, Evanston, IL, USA.ORCID http://orcid.org/0000-0002-5594-0599
Andreas RammingDepartment of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Ulmenweg 18, 91054, Erlangen, Germany.ORCID http://orcid.org/0000-0002-7003-501X
Jürgen RechDepartment of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Ulmenweg 18, 91054, Erlangen, Germany.ORCID http://orcid.org/0000-0002-2569-2029
Cheryl RosenDivision of Dermatology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.
Mrinal K SarkarDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-8505-4259
Georg SchettDepartment of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Ulmenweg 18, 91054, Erlangen, Germany.ORCID http://orcid.org/0000-0001-8740-9615
Börge SchmidtInstitute of Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Trilokraj TejasviDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-8186-8711
Heiko TraupeDepartment of Dermatology, University of Münster, Münster, Germany.
John J VoorheesDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0003-1856-785X
Eike Matthias WackerInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.ORCID http://orcid.org/0000-0002-2068-2550
Richard B WarrenDivision of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
Rachael WasikowskiDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0003-3544-3023
Stephan WeidingerDepartment of Dermatology, Venereology and Allergy, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.ORCID http://orcid.org/0000-0003-3944-252X
Xiaoquan WenDepartment of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-8990-2737
Zhaolin ZhangDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.
BSTOP study group
Estonian Biobank research team
Anne BartonCentre for Genetics and Genomics Versus Arthritis, The University of Manchester, Manchester, UK.ORCID http://orcid.org/0000-0003-3316-2527
Vinod ChandranSchroeder Arthritis Institute, Krembil Research Institute and Toronto Western Hospital, University Health Network and University of Toronto, Toronto, Ontario, Canada.
Tõnu EskoInstitute of Genomics, University of Tartu, Tartu, Estonia.
John FoersterCollege of Medicine, Dentistry, and Nursing, University of Dundee, Dundee, UK.
Andre FrankeInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.ORCID http://orcid.org/0000-0003-1530-5811
Dafna D GladmanSchroeder Arthritis Institute, Krembil Research Institute and Toronto Western Hospital, University Health Network and University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-9074-0592
Johann E GudjonssonDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-0080-0812
Wayne GulliverNewlab Clinical Research Inc, St. John's, NL, Canada.
Ulrike HüffmeierInstitute of Human Genetics, Universitätsklinikum Erlangen, FAU Erlangen-Nürnberg, Erlangen, Germany.ORCID http://orcid.org/0000-0001-6448-4671
Külli KingoDepartment of Dermatology and Venereology, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia.
Sulev KõksPerron Institute for Neurological and Translational Science, Nedlands, WA, 6009, Australia.
Wilson LiaoDeparment of Dermatology, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-7883-6439
Mari LøsetK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.ORCID http://orcid.org/0000-0003-3736-6551
Reedik MägiEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0002-2964-6011
Rajan P NairDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.
Proton RahmanMemorial University of Newfoundland, St. John's, NL, Canada.
André ReisInstitute of Human Genetics, Universitätsklinikum Erlangen, FAU Erlangen-Nürnberg, Erlangen, Germany.ORCID http://orcid.org/0000-0002-6301-6363
Catherine H SmithSt John's Institute of Dermatology, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.
Paola Di MeglioSt John's Institute of Dermatology, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.ORCID http://orcid.org/0000-0002-2066-7780
Jonathan N BarkerSt John's Institute of Dermatology, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.
Lam C TsoiDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.
Michael A SimpsonDepartment of Medical & Molecular Genetics, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK. michael.simpson@kcl.ac.uk.ORCID http://orcid.org/0000-0002-8539-8753
James T ElderDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA. jelder@umich.edu.ORCID http://orcid.org/0000-0003-4215-3294
Funding
Linkage analysis of familial psoriasis(Supplement)R01AR042742 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELDER, JAMES TILFORD · 1994 to 2021
$10.1MUniversity of Michigan Skin Biology and Diseases Resource-based CenterP30AR075043 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ANDRZEJ A. DLUGOSZ · 2019 to 2026
$6.6MGenetic and Genomic Dissection of Psoriatic ArthritisR01AR063611 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELDER, JAMES TILFORD, GLADMAN, DAFNA D · 2012 to 2023
$6.2MIdentification of Psoriatic Arthritis Genes in the MHCR01AR050511 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELDER, JAMES TILFORD · 2004 to 2013
$4.2MMHC and KIR Region Genomics in PsoriasisU01AI119125 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LIAO, WILSON · 2015 to 2019
$3.5MImmunogenomics and Systems Biology CoreUC2AR081033 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Johann Eli Gudjonsson, Lam Cheung Tsoi · 2022 to 2026
$3.3MCombined Analysis of Gene Expression and DNA Variation in PsoriasisR01AR054966 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELDER, JAMES TILFORD · 2007 to 2011
$3.2MFunctional genomics of GxE in cardiovascular disease: BPA, phthalates and their interactions with gene regulationR01ES033634 · NIEHS · WAYNE STATE UNIVERSITY · PI Francesca Luca, Roger Pique-Regi · 2022 to 2026
$2.5MResolving Methodological Challenges in Genomics Research: Causality, Risk Prediction, and Reproducibility: Administrative SupplementR35GM138121 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Xiaoquan Wen · 2020 to 2026
$2.4MIdentification of Causal Variants in PsoriasisR01AR065174 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LIAO, WILSON · 2013 to 2016
$1.8MFunctional Genomics of PsoriasisR01AR065183 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELDER, JAMES TILFORD · 2013 to 2016
$1.7MMechanisms of sex discrepancy in autoimmune disease: Regulation of the female-biased VGLL3 immune pathwayK08AR078251 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BILLI, ALLISON CHELSA · 2021 to 2025
$865kBundesministerium für Bildung und Forschung (Federal Ministry of Education and Research) 01EC1407A, 01EC1401CDeutsche Forschungsgemeinschaft (German Research Foundation) EXC 2167-390884018, CRC1181-2/project A05Deutsche Forschungsgemeinschaft (German Research Foundation) SI 236/8-1, SI236/9-1, ER 155/6-1DH | National Institute for Health Research (NIHR) BRC_1215_20006, NIHR302258, NIHR203308, BRC-1215-20014EC | European Regional Development Fund (Europski Fond za Regionalni Razvoj) 2014-2020.4.01.15-0012Eesti Teadusagentuur (Estonian Research Council) PUT1465, PRG1189, PRG1911, PRG1291Guy's and St Thomas' Charity STR130505Innovative Medicines Initiative (IMI) 821511LEO Pharma Research Foundation LF-OC-22-001033Maudsley Charity 980National Multiple Sclerosis Society (National MS Society) RG-1611-26299National Psoriasis Foundation (NPF) 814364NIAID NIH HHS U01 AI119125NIAMS NIH HHS K01 AR072129NIAMS NIH HHS K08 AR078251NIAMS NIH HHS P30 AR075043NIAMS NIH HHS R01 AR042742NIAMS NIH HHS R01 AR050511NIAMS NIH HHS R01 AR054966NIAMS NIH HHS R01 AR063611NIAMS NIH HHS R01 AR065174NIAMS NIH HHS R01 AR065183NIAMS NIH HHS UC2 AR081033NIEHS NIH HHS R01 ES033634NIGMS NIH HHS R35 GM138121Psoriasis Association RG2/10, ST1/19, ST3/20RCUK | Medical Research Council (MRC) MR/S003126/1U.S. Department of Health & Human Services | National Institutes of Health (NIH) K01 AR072129, P30 AR075043, UC2 AR081033, R01AR042742U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01AR050511, R01AR054966, R01AR063611, R01AR065183U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01ES033634, R35GM138121, K08 AR078251, R01AR065174U.S. Department of Health & Human Services | National Institutes of Health (NIH) U01AI119125
Abstract
Psoriasis is a common, debilitating immune-mediated skin disease. Genetic studies have identified biological mechanisms of psoriasis risk, including those targeted by effective therapies. However, the genetic liability to psoriasis is not fully explained by variation at robustly identified risk loci. To refine the genetic map of psoriasis susceptibility we meta-analysed 18 GWAS comprising 36,466 cases and 458,078 controls and identified 109 distinct psoriasis susceptibility loci, including 46 that have not been previously reported. These include susceptibility variants at loci in which the therapeutic targets IL17RA and AHR are encoded, and deleterious coding variants supporting potential new drug targets (including in STAP2, CPVL and POU2F3). We conducted a transcriptome-wide association study to identify regulatory effects of psoriasis susceptibility variants and cross-referenced these against single cell expression profiles in psoriasis-affected skin, highlighting roles for the transcriptional regulation of haematopoietic cell development and epigenetic modulation of interferon signalling in psoriasis pathobiology.
Indexed as
Genetic Predisposition to DiseasePsoriasisAllelesGenome-Wide Association StudyHumansPolymorphism, Single NucleotideTranscriptome
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.