Evidence map›Paper›PMID 40021520›Full record

ArticleBioprocess and biosystems engineering2025

Improvement of torularhodin production by Rhodotorula glutinis through the stimulation of physicochemical stress and application of the bioproduct as an additive in the food industry.

Júlio Gabriel Oliveira de Lima, Nathalia Vieira Porphirio Veríssimo, Caio de Azevedo Lima, Flávio Pereira Picheli, Ariela Veloso de Paula, Valéria de Carvalho Santos-Ebinuma

Abstract read
PubMed Publisher
In one paragraph

Article in Bioprocess and biosystems engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Júlio Gabriel Oliveira de LimaSchool of Pharmaceutical Sciences, Department of Bioprocess Engineering and Biotechnology, São Paulo State University (UNESP), Câmpus de Araraquara Rodovia Araraquara Jaú, Km 01 - s/n - Campos Ville, Araraquara, SP, CEP 14800-903, Brazil.
Nathalia Vieira Porphirio VeríssimoSchool of Pharmaceutical Sciences of Ribeirão Preto, Department of Pharmaceutical Sciences, São Paulo University (USP), Ribeirão Preto, Brazil.
Caio de Azevedo LimaSchool of Pharmaceutical Sciences, Department of Bioprocess Engineering and Biotechnology, São Paulo State University (UNESP), Câmpus de Araraquara Rodovia Araraquara Jaú, Km 01 - s/n - Campos Ville, Araraquara, SP, CEP 14800-903, Brazil.
Flávio Pereira PicheliSchool of Pharmaceutical Sciences, Department of Bioprocess Engineering and Biotechnology, São Paulo State University (UNESP), Câmpus de Araraquara Rodovia Araraquara Jaú, Km 01 - s/n - Campos Ville, Araraquara, SP, CEP 14800-903, Brazil.
Ariela Veloso de PaulaSchool of Pharmaceutical Sciences, Department of Bioprocess Engineering and Biotechnology, São Paulo State University (UNESP), Câmpus de Araraquara Rodovia Araraquara Jaú, Km 01 - s/n - Campos Ville, Araraquara, SP, CEP 14800-903, Brazil.
Valéria de Carvalho Santos-EbinumaSchool of Pharmaceutical Sciences, Department of Bioprocess Engineering and Biotechnology, São Paulo State University (UNESP), Câmpus de Araraquara Rodovia Araraquara Jaú, Km 01 - s/n - Campos Ville, Araraquara, SP, CEP 14800-903, Brazil. valeria.ebinuma@unesp.br.

Funding

CAPES 001Conselho Nacional de Desenvolvimento Científico e Tecnológico 312463/2021-9, 304399/2022-1Fundação de Amparo à Pesquisa do Estado de São Paulo 2021/06686-8, 2022/10809-0, 2023/01368-3, and 2023/10479-3
6 · The paper itself

Abstract

Carotenoids are pigments responsible for the red-orange colorations in valuable food products, and they can be produced via biotechnological means through microorganisms. Beyond their role as natural colorants, some carotenoids offer significant health benefits due to their antioxidant properties, making them valuable nutritional additives in the food industry. However, obtaining these compounds from natural sources with high quantity and purity poses challenges which reduces its market share when produced through a biotechnological route. This study proposes utilizing nutritional and physical stress to enhance carotenoid production, specifically torularhodin, using the yeast Rhodotorula glutinis CCT-2186. A Design of Experiments approach identified malt extract as the most suitable nitrogen source for maximizing carotenoid production. Furthermore, introducing a surfactant (Tween 80) in the culture medium, and extending the cultivation time to 96 h, led to an increase in torularhodin production, reaching a notable 2.097 mg/mL (377,68% more when compared to the initial condition) under the best condition [(%w/v): dextrose (1), KH

Indexed as

AnthocyaninsFood AdditivesFood IndustryRhodotorulaCarotenoidsCulture MediaAnthocyaninsCarotenoidsCulture MediaFood AdditivestorularhodinBioadditivesCarotenoid productionFood industryNutritional additivesPhysicochemical stress

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.