ArticleBiomacromolecules2025
Foreign Mucins Alter the Properties of Reconstituted Gastric Mucus.
Article in Biomacromolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- MUC5B and MUC5AC function in combination to regulate mucociliary transport on human airway epithelium.bioRxiv : the preprint server for biology · 2026Article
- High-Performance Bio-Glue From the Berries of a Parasitic Plant.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- N-Acetylcysteine-Functionalized Mixed Micelles Overcome Multiple Intestinal Barriers to Improve Oral Bioavailability and Antioxidant Protection of Imperatorin.Pharmaceutics · 2026Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During the course of evolution, distinct mucin subtypes have evolved, that predominantly occur in specific mucus variants of the body. A loss of this clear regional assignment is often associated with pathophysiological conditions such as asthma or gastric cancer. We here reconstitute mucus from different mucin subtypes to elucidate the influence of MUC5B/MUC2 contaminations on physiologically relevant properties of acidic MUC5AC gels as found in the stomach. Our findings indicate that these properties may be critically altered by the presence of an atypical mucin species. A weak integration of a contaminating mucin subtype into the host network yields weak viscoelastic gels with increased barrier capabilities. Unravelling the complex properties of mucosal barriers under disease conditions is crucial for the understanding of mucosal disease progression and for developing drug-carriers to traverse this biological barrier. Here, our results provide useful insights into mechanistic principles governing the physical properties of gastro-intestinal mucus.
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