Trial reportThe Lancet. Global health2025
Comparative effectiveness of daily therapeutic supplementation with multiple micronutrients and iron-folic acid versus iron-folic acid alone in children with mild-to-moderate anaemia in rural India: an open-label, randomised controlled trial.
Trial report in The Lancet. Global health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Effect of combined probiotic and iron-folic acid supplementation on iron status and gut inflammation markers: a randomized controlled trial among anaemic children.European journal of clinical nutrition · 2026Trial
- Impact evaluation of a population-based 'Screen and Treat for Anaemia Reduction (STAR)' strategy: a cluster randomised trial in rural Telangana, India.BMJ global health · 2025Trial
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnaemia is a major public health problem among children younger than 5 years and supplementation with iron-folic acid alone has not been found to result in desired improvements in haemoglobin concentrations. We aimed to compare the effect of supplementation with iron-folic acid plus multiple micronutrients versus iron-folic acid supplementation alone on haemoglobin concentration and cure rates in children with mild-to-moderate anaemia.
methodsIn this individually randomised controlled trial conducted in rural Haryana, India, children (aged 6-59 months) with mild-to-moderate anaemia (haemoglobin ≥7 to <11 g/dL) were randomly assigned (1:1) to receive either daily iron-folic acid plus multiple micronutrients or iron-folic acid alone for 90 days. The primary outcomes were mean haemoglobin concentration and the proportion of children cured of anaemia (haemoglobin ≥11 g/dL) at 90 days, assessed in the intention-to-treat population, which included all randomly assigned participants for whom primary outcome assessments were done. Safety was assessed in all randomly assigned participants. The trial was registered with the Clinical Trial Registry-India, CTRI/2020/10/028298.
findingsBetween March 1, 2021, and March 7, 2022, 1300 children were randomly assigned to the iron-folic acid plus multiple micronutrients group (n=648) or the iron-folic acid alone group (n=652). At baseline, 93 (20%) of 472 children had vitamin B
interpretationIn children with mild-to-moderate anaemia, supplementation with multiple micronutrients and iron-folic acid did not result in significant benefits compared with iron-folic acid alone. Efforts that focus on ensuring high compliance with iron-folic acid supplementation alone might achieve satisfactory rates of anaemia recovery.
fundingIndian Council of Medical Research and the Government of India.
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Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.