Evidence map›Paper›PMID 40021074›Full record

ArticleExperimental neurology2025

Role of substantia Nigra dopaminergic neurons in respiratory modulation and limitations of levodopa in Parkinson's disease.

Nicole C Miranda, Yasmin C Aquino, Tainá O Macedo, Luiz M Oliveira, Kairo A Albernaz-Mariano, Carolina D Munhoz, Jan-Marino Ramirez, Thiago S Moreira, Ana C Takakura

Abstract read
In one paragraph

Article in Experimental neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nicole C MirandaDepartment of Pharmacology, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, 05508-000, São Paulo, SP, Brazil.
Yasmin C AquinoDepartment of Pharmacology, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, 05508-000, São Paulo, SP, Brazil.
Tainá O MacedoDepartment of Pharmacology, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, 05508-000, São Paulo, SP, Brazil.
Luiz M OliveiraCenter for Integrative Brain Research, Seattle Children's Research Institute, 1900 9th Avenue, JMB10, Seattle, Washington, 98101, USA.
Kairo A Albernaz-MarianoDepartment of Pharmacology, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, 05508-000, São Paulo, SP, Brazil.
Carolina D MunhozDepartment of Pharmacology, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, 05508-000, São Paulo, SP, Brazil.
Jan-Marino RamirezCenter for Integrative Brain Research, Seattle Children's Research Institute, 1900 9th Avenue, JMB10, Seattle, Washington, 98101, USA.
Thiago S MoreiraDepartment of Physiology and Biophysics, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, 05508-000, São Paulo, SP, Brazil.
Ana C TakakuraDepartment of Pharmacology, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, 05508-000, São Paulo, SP, Brazil. Electronic address: takakura@icb.usp.br.

Funding

Integrative Consequences of HypoxiaP01HL090554 · NHLBI · UNIVERSITY OF CHICAGO · PI PRABHAKAR, NANDURI R · 2008 to 2017
$21.4M
Unraveling respiratory rhythm generation in the medullary networkR01HL126523 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI Jan M. Ramirez · 2015 to 2026
$8.3M
Unraveling the dynamic mechanisms underlying opioid respiratory depressionR01HL144801 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI Jan M. Ramirez · 2019 to 2026
$5.2M
Neuroglial interactions underlying the generation of the sighR01HL151389 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI RAMIREZ, JAN M. · 2020 to 2023
$3.2M
NHLBI NIH HHS P01 HL090554NHLBI NIH HHS R01 HL126523NHLBI NIH HHS R01 HL144801NHLBI NIH HHS R01 HL151389
6 · The paper itself

Abstract

The substantia nigra pars compacta (SNpc), a midbrain region enriched with dopaminergic neurons projecting to the dorsal striatum, is essential for motor control and has been implicated in respiratory modulation. In Parkinson's disease (PD) models, the loss of SNpc dopaminergic neurons correlates with baseline respiratory deficits, suggesting a potential link between dopaminergic dysfunction and respiratory impairments. To explore this, we used adult transgenic mice (Vglut

Indexed as

Antiparkinson AgentsDopaminergic NeuronsLevodopaParkinson DiseaseRespirationSubstantia NigraAnimalsMaleMiceMice, Inbred C57BLMice, TransgenicAntiparkinson AgentsLevodopaBrainstemBreathingHypercapniaHypoxia

Identifiers

PMID40021074
PMCPMC12273499

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.